Skip Navigation LinksHome > July 1996 - Volume 7 - Issue 4 > Correcting for Exposure Misclassification Using an Alloyed G...
Original Articles: PDF Only

Correcting for Exposure Misclassification Using an Alloyed Gold Standard.

Brenner, Hermann

Collapse Box


: Validation studies are increasingly employed to estimate and correct for exposure misclassification in epidemiologic studies. Often, however, the reference procedure used for validation is less than perfect. This phenomenon may lead to biased estimates of misclassification rates and hence of "corrected" measures of associations. In particular, it has been demonstrated that basic matrix correction procedures to correct for presumably nondifferential exposure misclassification may yield strongly misleading results in the case of an imperfect gold standard. The problem arises because apparent misclassification (misclassification with respect to an alloyed gold standard) is often differential even if true misclassification (misclassification with respect to true exposure status) is nondifferential. Therefore, correction procedures for differential rather than nondifferential misclassification should be employed in the presence of an alloyed gold standard.

(C) Lippincott-Raven Publishers.

Twitter  Facebook  ‚Äč


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.