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M2E Too! Mellick's Multimedia EduBlog
The M2E Too! Blog by Larry Mellick, MD, presents important clinical pearls using multimedia.

By its name, M2E Too! acknowledges that it is one of many emergency medicine blogs, but we hope this will serve as a creative commons for emergency physicians.

Thursday, December 1, 2016

I recently treated a patient with hemiplegic migraines successfully with bupivacaine cervical injections, a novel therapeutic technique using paraspinous cervical injections. The technique employs deep intramuscular injections of 1.5 mL of 0.5% bupivacaine bilaterally into the paraspinous muscles of the lower neck. (Read more in my October 2012 blog and see it demonstrated in a video at http://bit.ly/2ewC5n1.)

This headache and orofacial pain treatment was first described in 1996 by my twin brother, Gary Mellick, DO, a neurologist who did a pain fellowship. The exact mechanism is unknown, but the treatment appears to work centrally on the brain based on convincing observations. Evidence of central effects include resolution of cortical-related signs and symptoms such as nausea, photophobia, and allodynia. The first three cervical nerves that innervated the neck and scalp travel directly into the brain stem and the trigeminal caudate nucleus, a relay center important to other successful headache medications. This relay center in the brain stem also has synapses with cranial nerves 5, 7, 9, and 10 and antinociceptive centers such as the periaqueductal gray, nucleus raphe magnus, and the rostroventral medulla synapse, which have a profound antinociceptive effect. Neural connections to the cerebral cortex are also documented.

Until now, no actual physical evidence has documented central activity other than patient-reported relief of headache and nausea, photophobia, phonophobia, and allodynia. This recent pediatric patient with hemiplegic migraine demonstrated dramatic physical examination changes after the injection that were undeniable. He had been admitted before after presenting with right-sided headache and left-sided hemiplegia, but this time had other known complications of this condition when he came to the ED: He was altered and only slightly responsive to painful stimuli. Because this 12-year-old basketball player was quite tall for his age, four health care providers were required to lift him from the wheelchair to the gurney because he was incapable of assisting or following directions.

I consulted with his parents, and we decided to try the bilateral cervical injections with bupivacaine. The patient demonstrated only a slight painful response to the first injection, but he was able to have a conversation with his father and move all four extremities 15 minutes after the injections. He was able to stand shortly after that, but still had difficulty walking because of residual left-sided weakness. He was admitted for further evaluation and observation.

Hemiplegic migraine has two forms, the familial hemiplegic migraine and the sporadic hemiplegic migraine. The familial form is dominantly inherited, and genetic studies have implicated mutations in the genes that encode proteins involved in ion transportation. This type of migraine headache is usually accompanied by an aura featuring a motor deficit and at least one other symptom such as aphasia, vertigo, tinnitus, or visual and sensory problems. Protracted motor deficit, confusion, coma, and seizures or status epilepticus can also occur during a severe crisis. Diagnosis of this condition is made by the process of elimination. The patient, however, may simplify the situation by presenting with the diagnosis already established. Other family members, usually first- and second-degree relatives, may have been previously diagnosed with this condition.

My patient's two older brothers also have the condition. The neurologic deficit is real and may last for minutes to hours. Prolonged speech deficits and residual motor weakness can occur depending on which cerebral hemisphere is involved. Headaches develop during or after the deficit and are often accompanied by typical migraine signs and symptoms. Severe crises, however, can present with altered mental status and even a Glasgow coma score of 3. Patients also can experience hyperthermia (41°C), respiratory failure, major confusion, agitation, hallucinations, vomiting with the risk of aspiration, and seizures, including partial or generalized status epilepticus.

Workup includes documenting absence of hypoglycemia, a battery of standard laboratory tests and toxicology screens, and CT scan and MRI. A lumbar puncture is recommended in the presence of fever and altered mental status. Other potential studies include an EEG, ECG, and chest x-ray.​

This was the first hemiplegic migraine patient I had ever treated with cervical injections, and the outcome of headache relief and subsequent neurologic recovery was clinically dramatic. This patient's response provided further evidence supporting the centrally acting mechanism of this therapeutic intervention.

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This 12-year-old with hemiplegic migraine could not even walk upon arrival at the ED, but could raise his arms and move his legs 15 minutes after a bupivacaine cervical injection. Watch a video of that and of his father explaining his history.​


Tuesday, November 1, 2016

I have immense respect for a few pediatric emergency conditions. Post-surgical bleeding following a tonsillectomy and adenoidectomy (T&A) has given me several memorable patient care experiences over the years. Honestly, the word "memorable" is actually a euphemism for terrifying.

Part of the problem with post-T&A bleeding is the patient. Typically, it's a pediatric patient who for hours has been quietly bleeding into the posterior pharynx while quietly swallowing the evidence (e.g., blood). By the time the patient presents to the ED, a significant but unknown percentage of the child's total blood volume has been lost. We cannot begin to guess how much blood has actually been lost until the patient starts vomiting. Suddenly realizing that your pediatric patient is already in compensated shock is a frightening experience.

The problem with T&A surgery is that bleeding can come from four locations. Two adenoids and two tonsils are removed. The bleeding can occur immediately after the surgery or, more commonly, days to weeks later. Bleeding can occur in the nose and the mouth, and these are not easily accessible for applying direct pressure to stop the bleeding.

My most recent patient was a 5-year-old who presented with a nosebleed three weeks after her tonsillectomy and adenoid surgery. The nosebleed had already been going on for three hours by that time. Her mother had already applied oxymetazoline, an adrenergic receptor agonist, eight to 10 times her nose without success. Then the vomiting began. Emesis after emesis of large amounts of blood continued for the next hour while we waited for the ENT consultant to arrive.

The ENT's initial advice was to apply more oxymetazoline, a potentially dangerous medication, and he asked over the phone if we had tried to pack the nose, a silly question as far as I was concerned. Packing the nose of a frightened little girl with nares smaller than the tip of my little finger just wasn't going to happen without sedation. Nasal packing also didn't seem like the correct therapeutic intervention for bleeding from a post-surgical adenoidectomy site.

How do you stop bleeding from a post-surgical adenoidectomy site? This scenario is similar to stopping the bleeding of posterior epistaxis. My plan, if her condition deteriorated, was to insert a pediatric Foley catheter, blow up the balloon, and apply traction. Besides placing two of the largest intravenous catheters possible, I ordered a 20 mL/kg normal saline bolus and a blood type and cross. Her initial hemoglobin was 11.1 g/dL, and I briefly considered O-negative blood as her heart rate climbed and her pulse pressure narrowed. Thankfully, the signs of compensated shock subsided and the bleeding slowed before she was taken to the operating room to have her left bleeding adenoidectomy site treated. I checked a day or two later, and her hemoglobin had settled at 8.0 g/dL, a 3 g/dL drop.

What else could I have done? Using forceps to apply an epinephrine-soaked gauze to the posterior pharynx apparently works for bleeding tonsillectomy sites. Access to the adenoidectomy site is not guaranteed, however. Next time, I will use a laryngotracheal mucosal atomization device placed through the bleeding nares to deposit 1:10,000 or 1:100,000 epinephrine to my patient's posterior nasopharynx. Another potential but unproven option is the topical application of hemostatic agents such as fibrin sealant or thrombin with the mucosal atomization device. Intravenous tranexamic acid is also a consideration. The topical application of tranexamic acid has been used successfully in surgery to stop or slow bleeding.

Watch a video of a patient with post-T&A bleeding.​

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Monday, October 3, 2016

Ankle dislocations are usually the result of high-energy trauma that cause plantar flexion of the ankle combined with an inversion or eversion stress. These dislocations are typically described according to the direction of displacement of the talus and foot in relation to the tibia. Consequently, dislocation may be upward, posterior, medial, lateral, posteromedial, or anterior. 

Posterior dislocation of the talus is the most common form of ankle dislocation. Associated fractures are the rule rather than exception, and ligamentous disruption varies according to the type of dislocation. One of the most dramatic joint dislocations is the open, dislocated ankle. A principal concern, in addition to timely reduction, is the possibility of a neurovascular injury. Radiographs should not delay reduction in cases where vascular compromise or skin tenting is present. After reduction, reassessment of the neurovascular status, splinting, ankle elevation, and post-reduction radiography are accomplished. 

The reduction procedure is accomplished with the patient lying supine. After procedural sedation and analgesia, the knee is flexed to 90 degrees. Distraction of the foot, followed by a gentle force reversing direction of the dislocation is sometimes all that is needed, though a more forceful maneuver may be needed. Many open ankle fractures and dislocations will not be reduced unless the injury mechanism is first recreated. 

This important tenet of orthopedic surgery is frequently overlooked. When that happens, the joint dislocation reduction can be nearly impossible to accomplish. This video shows the initial failures of open ankle fractures and dislocation reductions by emergency medicine and orthopedic residents. Only after the operators regrouped and recreated the mechanism of injury were the open ankle dislocations successfully reduced.

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Watch a video showing an ankle injury being recreated so that the open dislocation can be reduced​.


Thursday, September 1, 2016

​How could a Lyme disease lookalike rash and anaphylaxis to meat have anything in common? As I found out recently, they do. They both have a common vector, the Lone Star Tick, which is also known by its formal name, Amblyomma americanum, and is found predominately in the East, Southeast, and Southwest. It is an aggressive tick that loves humans.

In fact, all three growth stages (adult, nymph, and larva) are known to feed on humans. Besides the common signs of irritation that often accompany a tick bite, a rash similar to the rash of Lyme disease has been commonly described. This "bull's-eye" rash is often accompanied by systemic symptoms such as fatigue, fever, headache, muscle, and joint pains. Even though the rash looks almost identical to the erythema migrans of Lyme disease, it isn't caused by Borrelia burgdorferi. In fact, researchers still have not isolated out the etiology of STARI or Southern Tick-Associated Rash Illness.

Treatment with doxycycline seems to be associated with disappearance of the rash and relief of the associated signs and symptoms. Yet, whether to treat is still considered the prerogative of the physician.

The Lone Star Tick is also implicated in causing growing numbers of humans to develop a strange allergy to meat. More specifically, the allergy is to a carbohydrate present in mammalian meat called galactose-alpha-1,3-galactose, or Alpha-Gal for short. The reaction may be delayed for several hours after eating mammal meat, causing confusion and misdiagnosis. As with any anaphylaxis condition, it can be severe and life-threatening.

This is what I love about medicine: the never-ending list of new discoveries that occur on a daily basis.

Watch this video showing removal of a female Lone Star Tick from a child, and hear a discussion of STARI and Alpha-Gal.​

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Monday, August 1, 2016

Geographic location and seasonal variations often dictate the frequency of specific emergencies. I have been impressed over the years how often my geographic location would determine the type of injuries and emergencies that would show up in my emergency department. 

My two years in Honolulu taught me a lot about illnesses and injuries associated with work and recreation in the Pacific Ocean. Seasonal variations also affect the types of emergencies we see. Fish hook removal injuries are a prime example. Already this spring and summer I have had a number of children present with fish hooks embedded in their flesh so it seems appropriate to review the various techniques described in textbooks and review articles for removing fish hooks. Some techniques are clearly more effective than others.

Retrograde Technique
This is simply pushing down on the shank and pulling out the hook. It may work with barbless hooks, but isn't very successful for barbed ones.

String Pull Technique
This is actually a pretty effective technique, and it is reportedly not too painful if done quickly. The shank is again pushed down on the skin, and a string is tied around the bend of the hook. Take precautions not to cause injury to the operator from a flying hook, and then abruptly yank the hook free with the string. The potential for additional tissue injury, however, seems significant.

​Needle Cover Barb Technique
This technique uses an 18-gauge needle to cover the barb of the hook. Ideally, the hook and needle are removed simultaneously. This technique is technically difficult, in my opinion, and it usually fails in my experience.

​Advance and Cut Technique
This technique maneuvers the fish hook barb to puncture through the skin, where the exposed barb is cut off with the appropriate tool. The remaining fish hook is effortlessly backed out. The only downside to this procedure is that deeply buried hooks or hooks with a narrow gap between the shank and the barb are not easily maneuvered to create a new puncture hole in the skin. Nevertheless, it is an excellent technique when it works.

Scalpel Barb Release Technique
This procedure uses a #11 scalpel blade to release the tissues around the barb. This technique is probably effective except for the fact that the wound size is enlarged and additional tissue damage occurs. My main criticism is that we are using a sledge hammer when a mallet will work just as effectively.

Finally, we formally name a new technique called the Needle Barb Release Technique. It is similar to the Scalpel Barb Release Technique, but uses an 18-gauge needle instead of a scalpel. I am confident that this technique has inadvertently been used over the years when the Needle Barb Cover Technique was attempted, but we recently decided to name it. The bottom line is that the fish hook is easily removed with minimal additional tissue injury when an 18-gauge needle is used to free the tissues around the fish hook barb.

Watch a video of the Needle Barb Release Technique​.

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About the Author

Larry Mellick, MD
Dr. Mellick is a professor of emergency medicine and pediatrics at Augusta University and is a former chairman of emergency medicine at the Medical College of Georgia and Loma Linda University Medical Center. He is also the founder of two pediatric emergency medicine programs at these two institutions. Currently, his medical YouTube channel is internationally popular and viewed by millions each month. Follow it here: https://www.youtube.com/user/lmellick.