Introduction: Breast cancer is considered to be a systemic disease, which means that most breast carcinoma metastasize before diagnosis of the primary lesion. S100A4, a member of the S100 family of proteins, is directly involved in driving the progression of metastatic disease. Genetic alteration of both phosphatase and tensin homologue deleted on chromosome 10 (PTEN) alleles occurs in almost all types of human cancers examined, with inactivation usually because of mutation accompanied by loss of heterozygosity. The purpose of this study was to investigate the expressions of PIEN and S100A4 in human breast carcinoma and to evaluate their clinicopathological implications during the tumorigenesis and progression of breast cancer.
Materials and methods: The expressions of PTEN and S100A4 in 55 cases of breast cancer were investigated immunohistochemically. Correlations between the expression of PTEN protein, S100A4, and clinicopathological features of breast cancers were analyzed.
Results: There were significantly negative correlations between the level of PTEN expression and histological grade and axillary lymph node status (P<0.05), but PTEN expression was not correlated with patients’ age and tumor size (P>0.05). PTEN expression showed a significant positive correlation with estrogen receptor and progesterone receptor expression of breast. There were significantly positive correlations between the level of S100A4 expression and patients’ age and tumor size (all P<0.05), but S100A4 expression was not correlated with histologic grade or lymph node metastasis (P>0.05). S100A4 expression showed a significant negative correlation with estrogen receptor and progesterone receptor expression. The expression of PTEN protein in breast cancer showed a significantly negative correlation with the expression of S100A4.
Conclusion: The combined detection of PTEN and S100A4 may serve as an important index to estimate the pathobiological behavior and prognosis of breast cancer.