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Effect of narrow-band ultraviolet B on the expression of human β-defensin 2 in psoriatic patients, using immunohistochemistry

Aly, Adel A.S.a; AbdElMaksoud, Rania A.S.a; El Gendi, Saba M.b; Amin, Olaa

Egyptian Journal of Pathology: July 2013 - Volume 33 - Issue 1 - p 42–49
doi: 10.1097/01.XEJ.0000429925.93864.f7
Original Articles

Background Administration of narrow-band ultraviolet B (NB-UVB) is a routine treatment modality for psoriasis, but its effect on human β-defensin 2 (HBD2) level has not been well studied.

Aim of the study The aim of the study was to assess immunohistochemically the expression of HBD2 in patients before treatment and compare the results with controls and also assess immunohistochemically the expression of HBD2 in psoriatic lesions before and after NB-UVB phototherapy treatment, thereby assessing the effect of NB-UVB phototherapy treatment on HBD2 expression.

Patients and methods This study included 30 patients with psoriasis and 30 age-matched and sex-matched controls.

HBD2 expression was detected by immunohistochemical analysis in patients before and after NB-UVB treatment. It was also detected in control specimens, which were obtained from excess skin that was removed as a routine during procedures such as abdominoplasty and partial thickness skin grafting in the plastic surgery department.

Results HBD2 was found to be highly expressed in normal individuals.

HBD2 was also found to be highly expressed in patients before NB-UVB treatment but showed a significant decrease in expression after treatment (P<0.001).

Conclusion The study found that there was a noticeable increase in the expression of HBD2 in normal individuals.

The present study shows that, in addition to a significant improvement in psoriasis, NB-UVB decreased HBD2 levels in healing psoriatic lesions.

Departments of aDermatology, Venereology and Andrology

bPathology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Correspondence to Rania A.S. AbdElMaksoud, MD, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt Tel: +00201229992543; e-mail: drranyah2002@ymail.com

Received January 5, 2013

Accepted March 12, 2013

©2013Egyptian Journal of Pathology