Genetic associations of chronic wound pain after surgery: BAPCAP24

Gin, T.; Meng, Z.; Liu, X.; Cheng, C.; Chan, M.

European Journal of Anaesthesiology: June 2011 - Volume 28 - Issue - p 5–6
Abstracts and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Best Abstracts - Runner-up Session 2

Chinese University of Hong Kong, Department of Anaesthesia and Intensive Care, Shatin, Hong Kong

Background and Goal of Study: Chronic postoperative wound pain is a major clinical problem. Depending on the type of surgery, between 10 and 40% patients develop persistent pain even after the surgical wound has apparently healed.

Although the causes are largely unclear, inheritable factors may be associated with this chronic pain. The purpose of this study is to identify the association of single nucleotide polymorphisms (SNPs) with chronic wound pain after major abdominal surgery.

Materials and Methods: The study was approved by the Clinical Research Ethics Committee. Patients undergoing open abdominal surgery gave written consent. Using the modified brief pain inventory, we recorded the severity of post‐surgical wound pain at 6 months after surgery. Venous blood was collected for genotyping using TaqMan assays.

The association between SNPs or haplotypes with chronic postoperative wound pain was tested with a multivariate regression model. A P value < 0.05 was considered statistically significant.

Results and Discussion: Of 228 patients who completed the follow‐up interviews, 91 patients (39.9%) reported persistent wound pain. Twenty patients (8.8%) had pain score > 5 (0= least and 10 = worst possible pain). We observed a lower rate of chronic wound pain in patients carrying minor allele for GTP cyclohydrolase 1 (GCH1), catechol‐O‐methyl transferase 1 (COMT1) and βarrestin2 genes (Table 1).

Further scanning of SNPs and analysis of haplotypes or linkage disequilibrium in these genes (regions) may help to identify functional genetic polymorphisms and other candidate genes that may contribute to the development of persistent pain after surgery.

Conclusions: Chronic wound pain after surgery is associated with some genetic polymorphisms.

© 2011 European Society of Anaesthesiology