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Gabapentin reduces cardiovascular responses to laryngoscopy and tracheal intubation

Memiş, D.*; Turan, A.*; Karamanloğlu, B.; Şeker, Ş.*; Türe, M.

European Journal of Anaesthesiology:
doi: 10.1017/S0265021506000500
Original Article
Abstract

Background and objective:: We have compared the effects of gabapentin on arterial pressure and heart rate at induction of anaesthesia and tracheal intubation in a randomized double‐blind study.

Methods:: Ninety normotensive patients (ASA I) undergoing elective surgery were divided into three groups of 30 patients each. Patients received oral placebo (Group I), 400 mg of gabapentin (Group II) or 800 mg of gabapentin (Group III) 1 h prior to surgery in the operating theatre. After induction of anaesthesia heart rate and mean arterial pressure were recorded at baseline 1, 3, 5, 10 and 15 min after intubation.

Results:: Patients receiving placebo and 400 mg gabapentin showed a significant increase in blood pressure and heart rate associated with tracheal intubation compared to baseline levels and Group III. There was significant decrease in heart rate and arterial pressure in Group III after intubation 1, 3, 5 and 10 min (P < 0.001, P < 0.001, P < 0.05 and P < 0.05, respectively) compared to Groups I and II.

Conclusion:: Given 1 h before operation gabapentin 800 mg blunted the arterial pressure and heart rate increase in first 10 min due to endotracheal intubation. Oral administration of gabapentin 800 mg before induction of anaesthesia is a simple and practical method for attenuating pressor response to laryngoscopy and tracheal intubation after standard elective induction.

Author Information

*Trakya University, Department of Anaesthesiology and Reanimation, Edirne, Turkey

Trakya University, Department of Biostatistic, Edirne, Turkey

Correspondence to: Dilek Memiş, Department of Anaesthesiology, Medical Faculty, Trakya University, 22030, Edirne, Turkey. E‐mail: dilmemis@mynet.com; Fax: +90 284 235 80 96

Accepted for publication 8 February 2006

First published online 4 April 2006

© 2006 European Society of Anaesthesiology