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Catatonia in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition

Francis, Andrew PhD, MD*; Fink, Max MD*; Appiani, Francisco MD†; Bertelsen, Aksel MD‡; Bolwig, Tom G. MD, DMSc§; Bräunig, Peter MD∥; Caroff, Stanley N. MD¶; Carroll, Brendan T. MD#; Cavanna, Andrea Eugenio MD**; Cohen, David MD, PhD††; Cottencin, Olivier MD, PhD‡‡; Cuesta, Manuel J. MD§§; Daniels, Jessica MD∥∥; Dhossche, Dirk MD, PhD¶¶; Fricchione, Gregory L. MD##; Gazdag, Gabor MD, PhD***; Ghaziuddin, Neera MD†††; Healy, David MD‡‡‡; Klein, Donald MD§§§; Krüger, Stephanie MD∥; Lee, Joseph W.Y. MBBS∥∥∥; Mann, Stephan C. MD¶¶¶; Mazurek, Michael MD###; McCall, W. Vaughn MD, MS****; McDaniel, William W. MD††††; Northoff, Georg MD, PhD, FRCPC‡‡‡‡; Peralta, Victor MD, PhD§§; Petrides, Georgios MD§§§§; Rosebush, Patricia MScN, MD###; Rummans, Teresa A. MD∥∥∥∥; Shorter, Edward PhD¶¶¶¶; Suzuki, Kazumasa MD####; Thomas, Pierre MD, PhD‡‡; Vaiva, Guillaume MD‡‡; Wachtel, Lee MD*****

doi: 10.1097/YCT.0b013e3181fe28bd

From the *Department of Psychiatry and Behavioral Science, SUNY Stony Brook, Stony Brook, NY; †Universidad de Buenos Aires, Buenos Aires, Argentina; ‡Århus University Hospital Risskov; §Copenhagen University Hospital, Copenhagen, Denmark; ∥Charite University Medicine Berlin, Berlin, Germany; ¶University of Pennsylvania School of Medicine, Philadelphia, PA; #College of Osteopathic Medicine, Ohio University, Athens, OH; **University of Birmingham, Birmingham, UK; ††University Pierre & Marie Curie, GH Pitié-Salpétrière, Paris, France; ‡‡University of Lille, Lille, France; §§Virgen del Camino Hospital, Pamplona, Spain; ∥∥Weill Cornell Medical College, New York, NY; ¶¶University of Mississippi, Jackson, MS; ##Harvard Medical School, Boston, MA; ***Semmelweis University, Budapest, Hungary; †††University of Michigan, Ann Arbor, MI; ‡‡‡Cardiff University, Wales, UK; §§§Columbia University, New York, NY; ∥& par;∥University of Western Australia, Perth, Australia; ¶¶¶University of Louisville School of Medicine, Louisville, KY; ###McMaster University, Hamilton, Ontario, Canada; ****Wake Forest University, Winston-Salem, NC; ††††Eastern Virginia Medical School, Norfolk, VA; ‡‡‡‡University of Ottawa, Ottawa, Canada; §§§§Albert Einstein College of Medicine, Zucker Hillside Hospital, New York, NY; ∥∥∥∥Mayo Clinic, Rochester, MN; ¶¶¶¶University of Toronto, Toronto, Canada; ####Sendai City Hospital, Sendai, Japan; and *****Kennedy Krieger Institute, Johns Hopkins School of Medicine, Baltimore, MD (e-mail:

Received for publication August 22, 2010; accepted August 23, 2010.

Each author acknowledges no financial relationships with commercial interests relevant to this editorial.

As international scholars of catatonia, we are concerned that the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) proposes to delete the codes 295.2 (schizophrenia, catatonic type) and 293.89 (catatonia secondary to a medical condition) and to substitute a noncoded "catatonia specifier" as the principal identifier. We believe that these changes will badly serve clinical practice and research. We advocate a unique and broadly defined code for catatonia in DSM-V.

Catatonia is common among hospitalized psychiatric patients, including adults, adolescents, and occasionally children. In the 10 principal prospective studies from sites around the world, catatonia syndrome was identified in a mean (SEM) percentage of 9.8% (1.4%) of adult admissions (Table 1). These patients have multiple signs of catatonia (commonly >5); 68% (6%) are mute, and 62% (3%) are negativistic or withdrawn. Some are unable to eat, requiring parenteral nutrition and/or medication.

Once catatonia is recognized, first-line treatment with benzodiazepines usually brings prompt relief, although high doses may be needed. If catatonia persists, electroconvulsive therapy is often rapidly beneficial. Every prospective study confirms that catatonia syndrome exists, occasionally becomes malignant, and requires prompt treatment.

Under the proposed new guidelines for DSM-V, patients with catatonia syndrome will lack an informative diagnosis. Mutism, negativism, and withdrawal prevent assessment for mood, cognitive, and psychotic symptoms and impede proper delineation of episodes of prior illness. Without findings for a specific diagnosis, it is rational to use a provisional diagnosis of the catatonia syndrome to allow tests and treatments to proceed. Lacking recognition and treatment, catatonia may persist or worsen with adverse or life-threatening results. On the other hand, when patients with catatonia are identified and treated, they become verbal and interactive, allowing interviews and more definitive diagnoses, regardless of the primary pathological findings.

When patients cannot provide information, clinicians may conflate or misdiagnose catatonia with schizophrenia (as in the DSM-IV schema), impute a psychotic process, foster the unproven use of neuroleptics, and risk adverse effects, such as conversion to malignant catatonia or the neuroleptic malignant syndrome. Similarly, assignment of catatonia to "psychosis not otherwise specified" (298.9, DSM-IV and DSM-V) would be erroneous because these patients often either lack hallucinations and delusions or cannot be assessed for them.

The proposed elimination of DSM-IV "catatonia due to a general medical condition" (293.89) renders the coding for catatonia arising from general medical conditions problematic. At clinical presentation, the medical/toxic factors are rarely known, as time is often needed to identify these etiologies.

We also note that noncoded specifiers are not useful for research on nosology, treatment, and outcome.

To address all these issues, we urge inclusion in DSM-V of a specific diagnostic code for catatonia. One simple option is to retain the 293.89 code but revise its formulation to broadly encompass the catatonia syndrome without imputing a link to either primary psychiatric or general medical conditions. A unique and broadly defined code would foster recognition of the catatonia syndrome and permit research on nosology, treatment, and outcome. These goals are not met with the DSM-V plan for noncoded modifiers.

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