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Concomitant Anticonvulsants With Bitemporal Electroconvulsive Therapy: A Randomized Controlled Trial With Clinical and Neurobiological Application

Rakesh, Gopalkumar MD; Thirthalli, Jagadisha MD; Kumar, Channaveerachari Naveen MD; Muralidharan, Kesavan MD; Phutane, Vivek H MD; Gangadhar, Bangalore N MD

doi: 10.1097/YCT.0000000000000357
Original Studies

Background: Electroconvulsive therapy (ECT) is an effective treatment for major affective disorders. The combined use of ECT and anticonvulsant mood stabilizers is a common clinical scenario. There is dearth of systematic studies on the use of this combination with regard to clinical or cognitive outcomes.

Objective/Hypothesis: We aimed to compare clinical improvement and cognitive adverse effects between patients who received only ECT versus those who received ECT and anticonvulsants. We hypothesized that improvement would be fastest in patients who received only ECT.

Methods: We conducted a randomized controlled trial in which patients prescribed ECT while being treated with anticonvulsants were randomized into 3 groups: full-dose (FD), half-dose (HD), and stop anticonvulsant. A blind rater assessed clinical improvement in patients using rating scales [Young’s Mania Rating Scale (YMRS) and Clinical Global Impression] for clinical improvement and cognitive adverse effects (Postgraduate Institute memory scale). Analysis was done using mixed-effects modeling to delineate differences in clinical and cognitive outcomes across the 3 arms of the study over the course of ECT.

Results: Of the 54 patients recruited, 36 patients went into treatment allocation arms per the initial randomization plan. The main anticonvulsants prescribed were sodium valproate and carbamazepine. Patients in the 3 groups were comparable on clinical features. The most common diagnosis was bipolar affective disorder—with current episode of mania. Overall, there was no difference across the 3 groups in final clinical outcome scores (YMRS and Clinical Global Impression) when analyzed as intention to treat (ITT) or “as treated.” In both analyses, group × time interaction was significant when comparing trend of YMRS scores between the FD anticonvulsant group and the HD group from baseline to last ECT (P = 0.0435 in ITT and P = 0.0055 in as treated). Patients in the FD group improved faster than those in the HD group. There were no differences across the 3 groups with regard to their cognitive adverse effects in the ITT analysis; “as-treated analysis” showed the HD patients to have performed poorly on some domains. Seizure parameters showed no significant difference across the 3 groups.

Conclusion: This is a preliminary prospective study examining whether coprescription of anticonvulsants with ECT affected clinical or cognitive outcomes. The most important takeaway point from this study is the significant reduction in YMRS scores when ECT was given with FD anticonvulsant compared with halving the dose (HD) of anticonvulsant. This difference was shown in both ITT and as-treated analysis. There is a need for more prospective studies to examine this clinical question.

From the *Department of Psychiatry and Behavioral Sciences, Duke University Medical Center Durham, NC; †Department of Psychiatry National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India; and ‡Goulburn Valley Area Mental Health Service (GVAMHS), Shepparton, VIC, Australia.

Received for publication November 11, 2015; accepted August 15, 2016.

Reprints: Gopalkumar Rakesh, MD, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center Durham, NC 27705 (e-mail: rg153@dm.duke.edu).

The study was funded by the Indian Council of Medical Research dissertation grant for residents.

The authors have no conflicts of interest or financial disclosures to report.

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