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Journal of ECT:
doi: 10.1097/YCT.0000000000000077
Images in Clinical ECT

Images in Electroconvulsive Therapy: Electroconvulsive Shocks Dose-Dependently Increase Dendritic Arborization in the CA1 Region of the Rat Hippocampus

Smitha, Jangama S. M. MSc (Medical Anatomy)*; Roopa, Ravindranath MBBS, MS (Anatomy)*; Khaleel, Nagarchi MSc (Medical Anatomy)*; Kutty, Bindu M. PhD; Andrade, Chittaranjan MD

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Abstract

Stress and depression are associated with impaired neuroplasticity in the hippocampus: there is decreased dendritic arborization and synaptogenesis, which is hypothesized to explain decreased adaptive competence of the organism. Representative light microscopy images are presented that show that 6 once-daily electroconvulsive shocks (ECSs) dose-dependently increased dendritic arborization in the CA1 region of the hippocampus in healthy, adult, male Wistar rats (n = 10 in each of sham, 10-mC, and 40-mC ECS groups). These neuroplasticity changes, identified 1 month after the last ECS, may explain a part of the mechanism of action of electroconvulsive therapy in conditions such as depression.

Copyright © 2014 by Lippincott Williams & Wilkins

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