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Neural Basis of tDCS Effects on Auditory Verbal Hallucinations in Schizophrenia: A Case Report Evidence for Cortical Neuroplasticity Modulation

Nawani, Hema MSc; Kalmady, Sunil V. MSc; Bose, Anushree MA; Shivakumar, Venkataram MBBS; Rakesh, Gopalkumar MD; Subramaniam, Aditi MS; Narayanaswamy, Janardhanan C. MD; Venkatasubramanian, Ganesan MD

doi: 10.1097/YCT.0b013e3182a35492
Brief Clinical Report Letters

Abstract: Transcranial direct current stimulation (tDCS) has been reported to ameliorate auditory hallucinations that are nonresponsive/minimally responsive to antipsychotic treatment in schizophrenia. The neurobiological basis of the tDCS effects in ameliorating auditory hallucinations is yet to be explored. In this case report, for the first time, using the novel method for noninvasive assessment of cortical plasticity, we demonstrate potential neuroplasticity effect of tDCS in improving treatment-resistant auditory hallucinations in a schizophrenic patient.

From the Schizophrenia Clinic, Department of Psychiatry and Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India.

Received for publication June 1, 2013; accepted July 1, 2013.

Reprints: Ganesan Venkatasubramanian, MD, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India (e-mail: venkat.nimhans@yahoo.com).

The authors have no conflicts of interest or financial disclosures to report.

Supported by the Department of Science & Technology, Government of India (H.N., G.R., A.S., and J.C.N.); by the Wellcome Trust/DBT India Alliance (S.V.K. and A.B.); and by the Indian Council of Medical Research (V.S.).

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