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Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

Saricicek, Vahap MD*; Sahin, Levent MD*; Bulbul, Feridun MD; Ucar, Sevgi MD*; Sahin, Mehrican MD

doi: 10.1097/YCT.0b013e3182972bd2
Original Studies

Background: We aimed to compare the effects of succinylcholine and rocuronium-sugammadex on development of myalgia and headache after electroconvulsive therapy (ECT).

Methods: Forty-five patients undergoing ECT were enrolled in the study. Anesthesia induction was provided with propofol 1 mg/kg intravenously (IV) + succinylcholine 1 mg/kg IV in group S (n = 24) and propofol 1 mg/kg IV + rocuronium 0.3 mg/kg IV in group R (n = 21). Sugammadex 4 mg/kg IV was administered to group R after the motor seizure. The first 3 ECT sessions were evaluated on the basis of time to onset of spontaneous respiration following the induction, time to eye-opening response to verbal stimuli, and visual analog scale (VAS) scores for myalgia and headache at hours 2, 6, 12, and 24 following the ECT for all patients.

Results: The times to onset of spontaneous respiration and eye-opening response to verbal stimuli were significantly shorter in all the 3 sessions in group R compared with group S (P < 0.002). Myalgia VAS scores at hours 2, 6, and 12 and the headache VAS scores at hours 2 and 6 were significantly higher in group S versus group R (P < 0,015).

Conclusions: We concluded that the rates of myalgia and headache after ECT were significantly lower in group R than in group S, and also the awakening time (spontaneous respiration and opening the eyes in response to verbal stimuli) was significantly shorter in group R compared with group S.

From the *Department of Anesthesiology and Reanimation, †Department of Psychiatry, Faculty of Medicine, University of Gaziantep, and ‡Department of Anesthesiology, Obstetrics & Gynecology Hospital, Gaziantep, Turkey.

Received for publication February 12, 2013; accepted April 2, 2013.

Reprints: Vahap Saricicek, MD, Department of Anesthesiology and Reanimation, Gaziantep University Medical Faculty, 27310 Sahinbey, Gaziantep, Turkey (e-mail:

Financial source was provided by Gaziantep University.

The authors have no conflicts of interest to report.

© 2014 by Lippincott Williams & Wilkins