You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Electroconvulsive Therapy Attenuates Dendritic Arborization in the Basolateral Amygdala

Khaleel, Nagarchi MSc (Medical Anatomy)*; Roopa, Ravindranath MBBS, MS (Anatomy)*; Smitha, Jangama S.M. MSc (Medical Anatomy)*; Andrade, Chittaranjan MD

Journal of ECT:
doi: 10.1097/YCT.0b013e318282a6b1
Images in Clinical ECT
Abstract

Abstract: Stress and depression are associated with aberrant neuroplasticity in the amygdala: there is increased dendritic arborization and synaptogenesis, perhaps explaining the increased anxiety and fear that are often apparent in depressed patients. Light microscopy images are presented, which show that 6 once-daily high (but not low)-dose electroconvulsive shocks attenuated dendritic arborization in the basolateral amygdala of Wistar rats, which changes were apparent even 1 month after the last electroconvulsive shock. These changes may explain a part of the mechanism of action of electroconvulsive therapy in conditions such as depression and posttraumatic stress disorder.

Author Information

From the *Department of Anatomy, St. John’s Medical College; and †Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Received for publication November 27, 2012; accepted December 11, 2012.

Reprints: Chittaranjan Andrade, MD, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India (e-mail: andradec@gmail.com).

The authors have no conflicts of interest or financial disclosures to report.

Ravindranath Roopa and Jangama S.M. Smitha contributed equally as second authors.

© 2013 by Lippincott Williams & Wilkins