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Vagus Nerve Stimulation in Treatment-Resistant Depression: Acute and Follow-Up Results of an Italian Case Series

Dell’Osso, Bernardo MD*; Oldani, Lucio MD*; Palazzo, M. Carlotta MD*; Balossi, Ilaria MD*; Ciabatti, Mariateresa MD*; Altamura, A. Carlo MD

doi: 10.1097/YCT.0b013e3182735ef0
Original Studies

Abstract: The present study evaluated short- and long-term efficacy and tolerability of augmentative vagus nerve stimulation (VNS) in a group of patients with treatment-resistant depression (N = 6). A statistically significant improvement in the Hamilton Depression Rating Scale (HDRS21) and Montgomery-Asberg Depression Rating Scale after 3 months (P = 0.039 and P = 0.05, respectively) was found in comparison with baseline (VNS implant). After 12 months, a statistically significant improvement was observed in the Hamilton Depression Rating Scale (HDRS21), Montgomery-Asberg Depression Rating Scale, and Clinical Global Impression (P = 0.01, P = 0.005, and P = 0.001, respectively). Patients showed an overall favorable tolerability. Present data support VNS short- and long-term efficacy and tolerability in a small group of patients with treatment-resistant depression. Further controlled investigation is necessary to confirm the present open findings.

From the Departments of *Psychiatry and †Mental Health, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Received for publication May 29, 2012; accepted September 7, 2012.

Reprints: Bernardo Dell’Osso, MD, Department of Psychiatry, University of Milan, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milano, Italy (e-mail: bernardo.dellosso@policlinico.mi.it).

The authors have no conflicts of interest or financial disclosures to report.

© 2013 Lippincott Williams & Wilkins, Inc.