Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making.
Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011.
Five open studies, 13 sham-controlled studies, and 2 meta-analysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43–0.68).
Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies.
From the Central European Institute of Technology (CEITEC), Masaryk University, and Department of Psychiatry Medical Faculty, Masaryk University Hospital, Brno, Czech Republic.
Received for publication December 21, 2011; accepted August 14, 2012.
Reprints: Radovan Prikryl, MD, PhD, Department of Psychiatry, University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic (e-mail: email@example.com).
This work was supported by the project “CEITEC (Central European Institute of Technology)” (CZ.1.05/1.1.00/02.0068) from European Regional Development Fund and by the project (Ministry of Health, Czech Republic) for conceptual development of research organization 65269705 (University Hospital Brno, Brno, Czech Republic).
The authors have no conflicts of interest or financial disclosures to report.