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Successful Treatment of Co-Occurring Catatonia and Obsessive-Compulsive Disorder With Concurrent Electroconvulsive Therapy and Benzodiazepine Administration

Makhinson, Michael MD, PhD*†; Furst, Benjamin Albert MD*†; Shuff, Michelle Kristina MD, MPH*; Kwon, Grace Eun DO

doi: 10.1097/YCT.0b013e318254c2ea
Online Articles

Abstract: Catatonia, associated with a variety of medical and psychiatric conditions such as mood disorders and schizophrenia, is frequently treated with either benzodiazepines or with electroconvulsive therapy (ECT) in treatment-resistant cases. Simultaneous treatment with both is usually avoided. Here, we report a case of the use of the benzodiazepine antagonist flumazenil before ECT to facilitate the simultaneous use of lorazepam and ECT for the treatment of co-occurring catatonia and obsessive-compulsive disorder. Both catatonia and obsessive-compulsive disorder symptoms improved in the patient. Physicians should be aware of flumazenil as a clinical tool for use in treatment-resistant cases.

From the *Department of Psychiatry and Biobehavioral Science, UCLA School of Medicine, Los Angeles, and †Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA.

Received for publication January 31, 2012; accepted March 8, 2012.

Reprints: Michael Makhinson, MD, PhD, Department of Psychiatry, Harbor-UCLA Medical Center, 1000 West Carson St, Box 8, Torrance, CA 90509 (e-mail: mmakh@ucla.edu).

The authors have no conflicts of interest or financial disclosures to report.

© 2012 by Lippincott Williams & Wilkins