Institutional members access full text with Ovid®

Share this article on:

Simultaneous Low (1 Hz)- and High (10 Hz)-Frequency Bilateral Transcranial Magnetic Stimulation in a Patient With Severe Depression and Crohn Disease

Rosa, Moacyr Alexandro MD, PhD*†; Andrade, Marco Aurelio MD*†; Abdo, Guilherme Lozi MD*†; Rosa, Marina Odebrecht MS, MD

doi: 10.1097/YCT.0b013e3182545187
Online Articles

Abstract: We present a case report in which electroconvulsive therapy had a good effect for the treatment of depression in association with Crohn disease, but adverse effects limited its use. Repetitive transcranial magnetic stimulation was tried both in a conventional way (high frequency over the left dorsolateral prefrontal cortex) and in a bilateral sequential way (high frequency in the same region followed in the same session by low frequency on the right side). Finally, bilateral simultaneous stimulation (high frequency over the left and low frequency over the right side) was tried and resulted in a response similar to that of electroconvulsive therapy.

From the *Federal University of São Paulo, and †Instituto de Pesquisas Avançadas em Neuroestimulação (IPAN), Sao Paulo, Brazil.

Received for publication February 22, 2012; accepted February 22, 2012.

Reprints: Moacyr Alexandro Rosa, MD, PhD, Rua Vergueiro, 1855 cj. 46, São Paulo, SP, CEP 04101-000, Brazil (e-mail:

The authors have no conflicts of interest.

Financial disclosures: Dr. Moacyr Alexandro Rosa is a paid consultant for Neurosoft do Brasil.

Drs. Marco A. Andrade, Guilherme L. Abdo, and Marina O. Rosa have no financial disclosures.

© 2012 by Lippincott Williams & Wilkins