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Iodine-123 Fluoropropyl-Carbomethoxy-3-β-(4-Iodophenyltropane) Single-Photon Emission Computed Tomography Findings Before and After Electroconvulsive Therapy in Major Depressive Disorder With Parkinsonism

Bui, Eric MD, PhD*; Delrieu, Julien MD; Wagner, Thomas MD; Rieu, Julie MD*; Véry, Etienne MD*; Letamendia, Clara MD*; Payoux, Pierre MD, PhD; Schmitt, Laurent MD*

doi: 10.1097/YCT.0b013e31821646b6
Case Reports

Background To date, only a few cases of improvement of Parkinsonism in depressed patients treated with electroconvulsive therapy (ECT) have been reported. However, no functional imaging data are available to support this finding.

Objective To describe the first observation of increase in dopamine transporter uptake after ECT.

Methods Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomographic imaging was conducted in a 77-year-old depressed patient displaying symptoms of Parkinson disease (PD) before and after a series of 12 bilateral ECTs.

Results The patient displayed improvement in PD symptoms and increase in dopamine transporter uptake after ECT.

Conclusions Our observation suggests that the PD symptoms and decrease in striatal uptake appearing in the context of a depressive episode might warrant further attention, as they might be reversible.

From the *Laboratoire du Stress Traumatique-LST (JE 2511), Université de Toulouse, UPS; †Service de Médecine Interne Gériatrique et Gérontologie Clinique, Gerontopôle, and ‡Service de Médecine Nucléaire Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

Received for publication December 16, 2010; accepted January 21, 2011.

Reprints: Eric Bui, MD, PhD, Laboratoire du Stress Traumatique-LST (JE 2511), Université de Toulouse, UPS, Hôpital Casselardit, 170 av. de Casselardit, 31059 Toulouse Cedex 9, France (e-mail: bui.e@chu-toulouse.fr).

The authors have no conflict of interest to declare.

© 2011 Lippincott Williams & Wilkins, Inc.