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Journal of ECT:
doi: 10.1097/YCT.0b013e3181926ada
Case Reports

Successful Use of Donepezil in Treatment of Cognitive Impairment Caused by Maintenance Electroconvulsive Therapy: A Case Report

Rao, Naren P. MBBS, MD*; Palaniyappan, Pradeep MBBS*; Chandur, Jyothsna M Phil†; Venkatasubramanian, Ganesan MBBS, MD*; Gangadhar, Bangalore N. MBBS, MD*

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Abstract

Cognitive deficits are commonly associated with maintenance electroconvulsive therapy (ECT). Treatment of these cognitive deficits is important but difficult. Cholinergic pathways are involved in these side effects, and donepezil, a cholinesterase inhibitor, may be useful for improvement of cognition. In this case report, we describe for the first time successful use of donepezil in treating cognitive deficits associated with maintenance ECT. The role of cholinesterase inhibitors in the treatment of cognitive deficits caused by ECT needs further studies.

© 2009 Lippincott Williams & Wilkins, Inc.

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