Skip Navigation LinksHome > September 2009 - Volume 25 - Issue 3 > Impacts of Switching Antidepressants After Successful Electr...
Journal of ECT:
doi: 10.1097/YCT.0b013e3181a8e2ac
Original Studies

Impacts of Switching Antidepressants After Successful Electroconvulsive Therapy on the Maintenance of Clinical Remission in Patients With Treatment-Resistant Depression: A Chart Review

Nakajima, Shinichiro MD*†; Ishida, Takuto MD†‡; Akaishi, Rei MD†§; Takahata, Keisuke MD†∥; Kitahata, Ryosuke MD†∥; Uchida, Hiroyuki MD, PhD†¶; Suzuki, Takefumi MD, PhD†#; Takeuchi, Hiroyoshi MD*†; Nomura, Kensuke MD†; Nakagawa, Atsuo MD†; Watanabe, Koichiro MD, PhD†; Kashima, Haruo MD, PhD†

Collapse Box

Abstract

Introduction: There is no consensus regarding whether a previously prescribed, that is, failed, antidepressant should be continued or switched after a successful electroconvulsive therapy (ECT) for the maintenance of clinical remission in patients with treatment-resistant depression (TRD). In this study, we conducted a chart review to examine impacts of the antidepressant switch after the successful ECT on 1-year outcome in patients with TRD.

Materials and Methods: This retrospective chart review included inpatients with TRD (ie, those who failed to respond to adequate trials of 2 distinctly different classes of antidepressants) who showed clinical remission after ECT. Readmission rate and social functioning 6 months and 1 year after the successful ECT were compared between patients who experienced an antidepressant switch and those who continued prior regimen.

Results: Twenty-eight patients (mean age, 59 years; 9 men) were followed-up for 1 year. The patients who changed antidepressants after ECT (n = 7) experienced a readmission significantly less frequent than the others (n = 21) in 1 year (0% vs 43%, P = 0.043). In addition, the former showed significantly better social contacts at 6 months (P = 0.022) and 1 year (P = 0.015). There were no significant differences in baseline characteristics between the 2 groups.

Conclusions: The patients who experienced an antidepressant switch after ECT required a readmission less frequently in 1 year than those who were maintained with the same antidepressant. The findings of this preliminary study suggest that a switch to another antidepressant after successful ECT may be encouraged for the maintenance of clinical remission in patients with TRD.

© 2009 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.