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Bemegride Lengthens Seizure Duration During Electric Convulsive Therapy in a Schizophrenic Patient With Increased Seizure Threshold

Katagai, Hiroshi MD, PhD*†; Yasui-Furukori, Norio MD, PhD*; Kikuchi, Atsuhiro*; Kaneko, Sunao*

doi: 10.1097/0b013e3181723725
Case Reports

A 48-year-old man who had a history of schizophrenia for 30 years was treated with electroconvulsive therapies. Because of poor seizure even at maximum electrical dosage, aminophylline was administered just before initiating electroconvulsive therapy. Although aminophylline augmentation lengthened the seizure duration, tachycardia and hypertension were observed. Therefore, we switched to bemegride, an antagonist to barbiturate, and seizure length was improved without any side effects. The present case suggested that bemegride is one of the alternative measures in patients with poor seizure quality.

From the *Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University; and †Department of Psychiatry, Hirosaki-Aiseikai Hospital, Hirosaki, Japan.

Received for publication February 21, 2008; accepted February 29, 2008.

Reprints: Norio Yausi-Furukori, MD, PhD, Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan (e-mail: yasufuru@cc.hirosaki-u.ac.jp).

© 2009 Lippincott Williams & Wilkins, Inc.