Skip Navigation LinksHome > March 2004 - Volume 20 - Issue 1 > Efficacy of ECT in Depression: A Meta-Analytic Review
Journal of ECT:
Original Article

Efficacy of ECT in Depression: A Meta-Analytic Review

Pagnin, Daniel MD, MSc; de Queiroz, Valéria MD, MSc; Pini, Stefano MD; Cassano, Giovanni Battista MD

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Abstract

Summary: This study analyzed the efficacy of electroconvulsive therapy (ECT) in depression by means a meta-analytic review of randomized controlled trials that compared ECT with simulated ECT or placebo or antidepressant drugs and by a complementary meta-analytic review of nonrandomized controlled trials that compared ECT with antidepressants drugs. The review revealed a significant superiority of ECT in all comparisons: ECT versus simulated ECT, ECT versus placebo, ECT versus antidepressants in general, ECT versus TCAs and ECT versus MAOIs. The nonrandomized controlled trials also revealed a significant statistical difference in favor of ECT when confronted with antidepressants drugs. Data analyzed suggest that ECT is a valid therapeutic tool for treatment of depression, including severe and resistant forms.

© 2004 Lippincott Williams & Wilkins, Inc.

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