The Journal of ECT

Skip Navigation LinksHome > March 2004 - Volume 20 - Issue 1 > Efficacy of ECT in Depression: A Meta-Analytic Review
Journal of ECT:
Original Article

Efficacy of ECT in Depression: A Meta-Analytic Review

Pagnin, Daniel MD, MSc; de Queiroz, Valéria MD, MSc; Pini, Stefano MD; Cassano, Giovanni Battista MD

Collapse Box


Summary: This study analyzed the efficacy of electroconvulsive therapy (ECT) in depression by means a meta-analytic review of randomized controlled trials that compared ECT with simulated ECT or placebo or antidepressant drugs and by a complementary meta-analytic review of nonrandomized controlled trials that compared ECT with antidepressants drugs. The review revealed a significant superiority of ECT in all comparisons: ECT versus simulated ECT, ECT versus placebo, ECT versus antidepressants in general, ECT versus TCAs and ECT versus MAOIs. The nonrandomized controlled trials also revealed a significant statistical difference in favor of ECT when confronted with antidepressants drugs. Data analyzed suggest that ECT is a valid therapeutic tool for treatment of depression, including severe and resistant forms.

© 2004 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.