McCall, Andrew A.; Swan, Erin E. Leary; Borenstein, Jeffrey T.; Sewell, William F.; Kujawa, Sharon G.; McKenna, Michael J.
Ear and Hearing. 31(2):156-165, April 2010.
doi: 10.1097/AUD.0b013e3181c351f2
Delivery of medications to the inner ear has been an area of considerable growth over the past several decades. Systemic delivery of medication destined for treatment of the inner ear is the foundation upon which newer delivery techniques have been developed. Investigators and clinicians have begun developing and utilizing techniques to deliver therapeutic agents locally. Intracochlear devices that leverage recent advances in microsystems technology are being developed to apply medications directly into the inner ear. The historical, current, and future delivery techniques and uses for inner ear drug delivery serve as the basis for this review.