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Egyptian Journal of Oral & Maxillofacial Surgery:
doi: 10.1097/01.OMX.0000423873.29024.fa
Original article

The effect of maxillary–mandibular fixation on salivary immunoglobulin A and serum interleukin-6 in patients with mandibular fractures

Mansour, Amra; Kamal, Abeerb; Moussa, Basmad; Dehis, Mohammedd; Gameel, Gloriac

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Abstract

Objectives: The aim of this study was to determine the possible effect of maxillary–mandibular fixation as a definitive treatment for mandibular fracture on some aspects of immunocompetence.

Study design: Sixteen patients with a fractured mandible were included in this study. They were selected from among those attending the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Oral and Dental Medicine, Cairo University. Salivary immunoglobulin A and interleukin-6 were the immunologic parameters used throughout this study.

Results: The level of salivary immunoglobulin A was increased significantly from the preoperative period to 1 week postoperatively; it then resumed a significant increase until the second week postoperatively and was decreased significantly at 4 weeks postoperatively. The level of serum interleukin-6 was increased significantly from the preoperative interval to 1 week postoperatively; it then resumed a significant increase until the second week postoperatively and was decreased significantly at 4 weeks postoperatively.

Conclusion: The present study revealed that maxillary–mandibular fixation as a definitive treatment for mandibular fractures has an immunosuppressive effect over a long period.

© 2013 Egyptian Associations of Oral and Maxillofacial Surgery

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