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Stability of Generic Meropenem Solutions for Administration by Continuous Infusion at Normal and Elevated Temperatures

Franceschi, Loretta BSc; Cojutti, Piergiorgio MD; Baraldo, Massimo MD; Pea, Federico MD

doi: 10.1097/FTD.0000000000000054
Short Communication

Abstract: Administration by continuous infusion may represent an effective tool for the treatment of multidrug-resistant gram-negative related infections with meropenem. Currently, no data on chemical stability of generic bioequivalent versions of meropenem over time are available. Triplicate samples of 5 mg/mL solutions of a generic meropenem formulation, Hospira, were evaluated for chemical stability at increasing temperatures (25°C, 30°C, 35°C, and 40°C) by means of a high-performance liquid chromatography technique over 4 separate days. Degradation of generic meropenem was both time and temperature dependent, and the aqueous solutions were stable for up to 8 hours in the temperature range between 25°C and 35°C, and for up to 5 hours at 40°C. Continuous infusion of generic meropenem Hospira may be applied in clinical settings with ambient temperature below 35°C, provided that the 5 mg/mL aqueous solution is reconstituted at most after 6–8 hours.

Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia; Department of Experimental and Clinical Medical Sciences, Medical School, University of Udine, Italy.

Correspondence: Federico Pea, MD, Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia and Department of Experimental and Clinical Medical Sciences, University of Udine, P.le S. Maria della Misericordia 3, Udine 33100, Italy (e-mail: pea.federico@aoud.sanita.fvg.it).

F. Pea has been on the speakers' bureau of and has been a board membership of AstraZeneca. The remaining authors declare no conflict of interest.

Received September 11, 2013

Accepted January 15, 2014

© 2014 by Lippincott Williams & Wilkins