Therapeutic Drug Monitoring

Skip Navigation LinksHome > February 2014 - Volume 36 - Issue 1 > Microneedle-Mediated Minimally Invasive Patient Monitoring
Therapeutic Drug Monitoring:
doi: 10.1097/FTD.0000000000000022
Review Article

Microneedle-Mediated Minimally Invasive Patient Monitoring

Donnelly, Ryan F.; Mooney, Karen; Caffarel-Salvador, Ester; Torrisi, Barbara M.; Eltayib, Eyman; McElnay, James C.

Collapse Box


Background: The emerging field of microneedle-based minimally invasive patient monitoring and diagnosis is reviewed. Microneedle arrays consist of rows of micron-scale projections attached to a solid support. They have been widely investigated for transdermal drug and vaccine delivery applications since the late 1990s. However, researchers and clinicians have recently realized the great potential of microneedles for extraction of skin interstitial fluid and, less commonly, blood, for enhanced monitoring of patient health.

Methods: We reviewed the journal and patent literature, and summarized the findings and provided technical insights and critical analysis.

Results: We describe the basic concepts in detail and extensively review the work performed to date.

Conclusions: It is our view that microneedles will have an important role to play in clinical management of patients and will ultimately improve therapeutic outcomes for people worldwide.

© 2014 by Lippincott Williams & Wilkins


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.