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Suspected Opioid Overdose Case Resolved by CYP2D6 Genotyping

Shaw, Kaitlyn D. BSc*,†,‡,§; Amstutz, Ursula PhD*,†,‡,§; Jimenez-Mendez, Ricardo MD, PhD*,†,‡,§; Ross, Colin J. D. PhD*,‡,§,¶; Carleton, Bruce C. PharmD*,†,‡,§

Therapeutic Drug Monitoring:
doi: 10.1097/FTD.0b013e31824a1e21
Grand Round
Abstract

Abstract: A 14-year-old female with suspected narcotic overdose had CYP2D6 genotyping performed to verify opiate intoxication. The role of pharmacogenetics in pain management and individualization of opiate pharmacotherapy is discussed.

Author Information

*Division of Translational Therapeutics, Department of Paediatrics, Faculty of Medicine, University of British Columbia

Pharmaceutical Outcomes Programme, BC Children's Hospital

Canadian Pharmacogenomics Network for Drug Safety

§Child and Family Research Institute

Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

The authors declare no conflict of interest.

Correspondence: Dr. Bruce C. Carleton, PharmD, Child and Family Research Institute, 950 West 28th Avenue, Rm A3-207, Vancouver, BC V5Z 4H4, Canada (e-mail: bcarleton@popi.ubc.ca).

Received November 1, 2011

Accepted January 7, 2012

© 2012 Lippincott Williams & Wilkins, Inc.