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Understanding HIV-1 Drug Resistance

Frenkel, Lisa M.*†; Tobin, Nicole H.*

Therapeutic Drug Monitoring:
Basel Proceedings
Author Information

From the Departments of *Pediatrics and †Laboratory Medicine, University of Washington, Seattle, WA.

Received for publication September 30, 2003; accepted December 13, 2003.

Reprints: Dr Lisa M. Frenkel, 4800 Sand Point Way, NE, 8G-1, Seattle, WA 98105 (e-mail:


Abstract: Infection with drug-resistant HIV-1 may result from the acquisition of mutant strains or from their selection within the individual; either can compromise the efficacy of antiretroviral therapy (ART). Drug-resistance testing is recommended to assist in the choice of ART. Herein, factors that contribute to the selection of drug-resistant virus and details important to the interpretation of the genotypic and phenotypic susceptibility test results are reviewed.

© 2004 Lippincott Williams & Wilkins, Inc.