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The Effect of Ethanol and pH on the Adsorption of Drugs From Simulated Gastric Fluid Onto Activated Charcoal

Bailey, David N.; Briggs, John R.

Therapeutic Drug Monitoring: June 2003 - Volume 25 - Issue 3 - p 310-313
Article

The effect of ethanol and pH on the adsorption of acetaminophen (ACET), phenobarbital (PHB), phenytoin (PHY), salicylic acid (SA), and theophylline (THEO) from simulated gastric fluid onto activated charcoal was studied. For the ethanol study, each drug was prepared at a concentration of 10 g/L in ethanol; in hydrochloric acid (HCl), 1.2 mol/L; and in HCl, 1.2 mol/L, containing 75% ethanol, 50% ethanol, and 25% ethanol (v/v), respectively. For the pH study, each drug was prepared at a concentration of 10 g/L in HCl, 1.2 mol/L, pH 1.0, and in buffers of pH 1.7, 3.0, 4.0, 4.8, 5.8, 6.5, 7.4, and 9.4. After the addition of 1 g of activated charcoal to 10 mL of each solution, it was incubated for one hour at 37 °C. For comparison, in each experiment a blank consisting of the solution without charcoal was also incubated. With increasing concentrations of ethanol, there were substantial decreases in the adsorption of ACET, PHB, and PHY to charcoal. Ethanol-induced decreases in the adsorption of SA and THEO were less pronounced. Changes in pH did not affect the adsorption of ACET, PHB, PHY, or THEO. However, the adsorption of SA was decreased slightly at pH 1.0 and 3.0.

Division of Laboratory Medicine, Department of Pathology, University of California, San Diego, San Diego, California

Received October 8, 2002; accepted January 7, 2003.

Address correspondence and reprint requests to David N. Bailey, M.D., Division of Laboratory Medicine, Department of Pathology, UCSD Medical Center, 200 West Arbor Drive, San Diego, California 92103–8320; E-mail: dnbailey@ucsd.edu

© 2003 Lippincott Williams & Wilkins, Inc.