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Therapeutic Drug Monitoring:
Article

A Simple Method for Quantifying Fentanyl, Sufentanil, or Morphine in Discard Syringes From Anesthesia Procedures

Holth, Laurel S. T.*†; Friesen, Robert‡; Green, Carol*; Krahn, John*

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Abstract

Fentanyl, sufentanil, and morphine are commonly used in the conduct of anesthesia. Medical staff working with these drugs are at high risk of addiction. To detect and prevent diversion, a method was developed to quantify these drugs in discard syringes using the BioRad REMEDi HS™ Drug Profiling System. For fentanyl, the lowest concentration detected is 0.1 μg/mL, and the assay is linear to 5.0 μg/mL; the within-run coefficient of variation (CV) is 0.9% (n = 5), and between-run CV is 2.5% (n = 20). For sufentanil, the lowest concentration detected is 0.5 μg/mL, and the assay is linear to 11.0 μg/mL; the within-run CV is 2.0% (n = 5), and the between-run CV is 2.4% (n = 20). For morphine, the lowest concentration detected is 0.5 μg/mL, and the assay is linear to 10.0 μg/mL; the within-run CV is 11.6% (n = 5), and between-run CV is 11.3% (n = 20). Other drugs commonly used in the operating room were checked for cross-reactivity on the REMEDi HS™; none cross-reacted. The REMEDi HS™ can be used for rapid, accurate quantification of fentanyl, sufentanil, and morphine in discard syringes from anesthesia procedures or related medical applications.

© 2002 Lippincott Williams & Wilkins, Inc.

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