Skip Navigation LinksHome > September 1990 - Volume 1 - Issue 3 > Methylisothiazolinone/Methylchloroisothiazolinone (Kathon CG...
American Journal of Contact Dermatitis:Official Journal of The American Contact Dermatitis Society:

Methylisothiazolinone/Methylchloroisothiazolinone (Kathon CG) Allergy: An Updated Review.

de Groot, Anton C.

Collapse Box


: Contact allergy to the cosmetics preservative methylisothiazolinone plus methylchloroisothiazolinone (MI/MCI, Kathon CG, Euxyl K 100) is reviewed. MI/MCI has a strong sensitizing capacity as shown by predictive tests. Its use in cosmetic products of the stay-on variety at levels of 7 ppm or more has caused many cases of sensitization; such application of the preservative should be discouraged. Use of MI/MCI in rinse-off products at low levels does not carry a significant risk of induction and/or elicitation of hypersensitivity reactions in consumers. Most cases of contact allergy can be demonstrated by patch testing with MI/MCI 100 ppm in water, which should be added to any standard series.

(C) 1990 Decker Publishing Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.


Article Tools


Article Level Metrics