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Crohn’s Disease and Pregnancy: The Impact of Perianal Disease on Delivery Methods and Complications

Hatch, Quinton M.D.1; Champagne, Bradley J. M.D.2; Maykel, Justin A. M.D.3; Davis, Bradley R. M.D.4; Johnson, Eric K. M.D.1; Bleier, Joshua S. M.D.5; Francone, Todd D. M.D.6; Steele, Scott R. M.D.1

doi: 10.1097/DCR.0b013e3182a41381
Original Contributions: Inflammatory Bowel Disease

BACKGROUND: The optimal delivery method in patients with Crohn’s disease is unknown, and there is no large-scale evidence on which to base decisions.

OBJECTIVE: The aim of this study was to compare delivery methods and outcomes in patients with and without Crohn’s disease.

DESIGN AND PATIENTS: The Nationwide Inpatient Sample and International Classification of Diseases, Ninth Revision codes were used to identify childbirth deliveries. Patients were stratified by the presence or absence of Crohn’s disease and perianal disease (anorectal fistula or abscess, rectovaginal fistula, anal fissure, and anal stenosis).

SETTINGS: A large population-cohort database was used for the analysis.

MAIN OUTCOME MEASURES: The primary outcomes measured were cesarean delivery and perineal lacerations.

RESULTS: Of 6,794,787 pregnant women who delivered, 2882 had a diagnosis of Crohn’s disease. Rates of cesarean delivery were higher in patients who had Crohn’s disease with (83.1%) and without (42.8%) perianal disease in comparison with patients who did not have Crohn’s disease with (38.9%) and without (25.6%) perianal disease (p < 0.001). Rates of 4th degree perineal lacerations were similar between patients who had or did not have Crohn’s disease without perianal disease (1.4% vs 1.3%), but these rates increased significantly in patients with perianal disease (12.3%, p < 0.001). On multivariate analysis, perianal disease (OR, 10.9; 95% CI, 8.3–4.1; p < 0.001) and smoking (OR, 1.6; 95% CI, 1.5–1.7; p < 0.001) were independently associated with higher rates of 4th degree laceration. Crohn’s disease was not independently associated with 4th degree laceration.

LIMITATIONS: This was a retrospective study with the inherent limitations of large databases.

CONCLUSIONS: Patients with Crohn’s disease have higher rates of cesarean delivery. Perianal disease predicts severe perineal laceration independent of the presence of Crohn’s disease. In the absence of perianal disease, the method of delivery in women with Crohn’s disease should be predicated on obstetric indication.

1Department of Surgery, Madigan Army Medical Center, Tacoma, Washington

2Division of Colorectal Surgery, Case Medical Center, Cleveland, Ohio

3Division of Colorectal Surgery, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts

4Department of Surgery, University of Cincinnati, Cincinnati, Ohio

5University of Pennsylvania Hospitals, Philadelphia, Pennsylvania

6University of Rochester Medical Center, Rochester, New York

Financial Disclosures: None reported.

Disclaimer: The results and opinions expressed in this article are those of the authors, and do not reflect the opinions or official policy of the United States Army or the Department of Defense.

Poster presentation at the meeting of the American Society of Colon and Rectal Surgeons, Phoenix, AZ, April 27 to May 1, 2013.

Correspondence: CPT Quinton Hatch, M.D., Madigan Army Medical Center, 9040-A Fitzsimmons Dr, Tacoma, WA 98431. E-mail: qhatch@gmail.com

© 2014 The American Society of Colon and Rectal Surgeons