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Low Rectal Cancer: Classification and Standardization of Surgery

Rullier, Eric M.D.1,2; Denost, Quentin M.D.1,2; Vendrely, Véronique M.D.2,3; Rullier, Anne M.D., Ph.D.2,4; Laurent, Christophe M.D., Ph.D.1,2

Diseases of the Colon & Rectum: May 2013 - Volume 56 - Issue 5 - p 560–567
doi: 10.1097/DCR.0b013e31827c4a8c
Original Contribution: Colorectal/Anal Neoplasia

BACKGROUND: Surgical treatment of low rectal cancer is controversial, and one of the reasons is the lack of definition and standardization of surgery in low rectal cancer.

OBJECTIVE: We classified low rectal cancers in 4 groups with the aim of demonstrating that most patients with low rectal cancer can receive conservative surgery without compromising oncologic outcome.

DESIGN: Patients with low rectal cancer <6 cm from anal verge were defined in 4 groups: type I (supra-anal tumors: >1 cm from anal ring) had coloanal anastomosis, type II (juxta-anal tumors: <1 cm from anal ring) had partial intersphincteric resection, type III (intra-anal tumors: internal anal sphincter invasion) had total intersphincteric resection, and type IV (transanal tumors: external anal sphincter invasion) had abdominoperineal resection. Patients with ultra-low sphincter-preserving surgery (types II-III) were compared with those with conventional sphincter-preserving surgery (type I).

OUTCOME MEASURES: Postoperative mortality, morbidity, surgical margins, local and distant recurrence, and survival were analyzed.

RESULTS: Of 404 patients with low rectal cancer, 135 were type I, 131 type II, 55 type III, and 83 type IV. There was no difference in local recurrence (5% to 9% vs 6%), distant recurrence (23% vs 23%), and disease-free survival (70%-73% vs 68%) at 5 years between ultra-low (types II-III) and conventional (type I) sphincter-preserving surgery. Predictive factors of survival were tumor stage and R1 resection but not the type of tumor or type of surgery.

LIMITATIONS: This study is limited by the retrospective analysis of a database, obtained from a single institution and covering a 16-year period.

CONCLUSION: Classification of low rectal cancers and standardization of surgery permitted sphincter-preserving surgery in 79% of patients with low rectal cancer without compromising oncologic outcome. This new surgical classification should be used to standardize surgery and increase sphincter-preserving surgery in low rectal cancer.

1Surgery Department, CHU Bordeaux, Saint-Andre Hospital, Bordeaux, France

2Bordeaux Segalen University, Bordeaux, France

3Radiotherapy Department, CHU Bordeaux, Haut-Leveque Hospital, Pessac, France

4Pathology Department, CHU Bordeaux, Pellegrin Hospital, Bordeaux, France

Financial Disclosures: None reported.

Correspondence: Eric Rullier, M.D., Service de Chirurgie Digestive, Hôpital Saint-André, 33075 Bordeaux, France. E-mail: eric.rullier@chu-bordeaux.fr.

© The ASCRS 2013