Skip Navigation LinksHome > January 2013 - Volume 56 - Issue 1 > Is Curative Resection and Long-term Survival Possible for Lo...
Diseases of the Colon & Rectum:
doi: 10.1097/DCR.0b013e3182741929
Original Contribution: Colorectal/Anal Neoplasia

Is Curative Resection and Long-term Survival Possible for Locally Re-recurrent Colorectal Cancer in the Pelvis?

Colibaseanu, Dorin T. M.D.1; Mathis, Kellie L. M.D.2; Abdelsatter, Zaid M. M.D.1; Larson, David W. M.D.2; Haddock, Michael G. M.D.3; Dozois, Eric J. M.D.2

Collapse Box

Abstract

BACKGROUND: A multimodality approach for locally recurrent colorectal cancer in the pelvis provides a significant survival advantage when negative margins are achieved. However, outcomes of surgical resection in patients who have locally re-recurrent disease in the pelvis are not well studied. Our aim was to assess the safety, feasibility of a negative margin resection, and survival outcomes in patients with pelvic locally re-recurrent colorectal cancer.

DESIGN: A retrospective review identified 406 patients who underwent surgery for locally recurrent colorectal cancer between 1997 and 2007. Patients who had locally re-recurrent disease in the pelvis who underwent curative-intent resection were identified.

RESULTS: Forty-seven patients (31 male) were identified. Median age was 57 years (range, 30–84 years). Median time to re-recurrence was 2.4 years (range, 0.5–5.6 years). Margin status following re-resection was R0 60%, R1 32%, and R2 8%. Nonbowel organs were resected en bloc in 81%, including 7 sacral resections. Intraoperative radiation was given to 77%. Morbidity occurred in 42%, with 6% requiring reoperation for complications. Thirty-day mortality was nil. Overall survival at 2 and 5 years was 83% and 33%. Disease-free survival at 2 and 5 years was 55% and 27%. Five-year survival for patients who had R0 and R1 resections was 37% and 42%, whereas no patients having an R2 resection survived beyond 2 years (p = 0.002).

CONCLUSIONS: In highly selected patients with re-recurrent colorectal cancer in the pelvis, we found that surgery could be performed safely and that a curative (R0) resection was possible in more than 50%. Two- and 5-year survival rates are comparable to results seen when surgery is done for first-time recurrences.

© The ASCRS 2013

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.