Skip Navigation LinksHome > August 2011 - Volume 54 - Issue 8 > Influence of Crohn's Disease Risk Alleles and Smoking on Dis...
Diseases of the Colon & Rectum:
doi: 10.1007/DCR.0b013e31821b94b3
Original Contribution

Influence of Crohn's Disease Risk Alleles and Smoking on Disease Location

Chen, Hongyan M.S.5; Lee, Alexander M.D.1; Bowcock, Anne Ph.D.2; Zhu, Wei Ph.D.5; Li, Ellen M.D., Ph.D.1,4; Ciorba, Matthew M.D.1; Hunt, Steven M.D.3

Collapse Box

Abstract

OBJECTIVE: Our objective is to assess the effect of genetic and environmental factors on Crohn's disease location.

DESIGN: We identified 628 patients with Crohn's disease within the Washington University database (April 2005 through February 2010) that had complete information on 31 Crohn's disease-associated genotypes and clinical information on disease location (L1 to L4), smoking, sex, race, and age at diagnosis. For statistical reasons, the 3 major NOD2 alleles (rs2066844, rs2066845, and rs2066847) were grouped together. Logistic regression incorporating all of the genotypes and clinical covariates, including smoking, was performed with stepwise variable selection and by best subset selection.

RESULTS: Stepwise variable selection selected 3 major covariates, composite NOD2 genotype, smoking, and TNFSF15 genotype, which are also the 3 covariates selected by the best subset method. Whereas the NOD2 genotype and smoking are positively associated with ileal (L1 + L3) disease, the TNFSF15 genotype is positively associated with isolated colonic (L2) disease.

LIMITATIONS: The ability to detect disease site associations in this single-center study may be limited by the population size, low allelic frequency, and/or low odds ratio of certain Crohn's disease risk alleles.

CONCLUSION: These results indicate that NOD2 genotype, smoking status, and TNFSF15 genotype should be included as covariates in assessing the effect of genetic and environmental factors on Crohn's disease site location.

© The ASCRS 2011

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.