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Expression of Estrogen and Progesterone Receptors in the Anal Canal of Women According to Age and Menopause

Parés, David M.D., Ph.D.1,3; Iglesias, Mar M.D.2; Pera, Miguel M.D., Ph.D.1; Pascual, Marta M.D., Ph.D.1; Torner, Ariadna M.D.2; Baró, Teresa M.D., Ph.D.2; Alonso, Sandra M.D.1; Grande, Luis M.D., Ph.D.1

Diseases of the Colon & Rectum:
doi: 10.1007/DCR.0b013e3181f05422
Original Contribution
Abstract

PURPOSE: Fecal incontinence is highly prevalent, especially in menopausal women. The aim of this study was to analyze the expression of estrogen and progesterone receptors in the anal canal of women in relation to menopausal status and age.

METHODS: Samples of hemorrhoidal tissue were obtained from 34 women undergoing hemorrhoidectomy. The patients were divided into 2 groups: group 1 consisted of women with a menstrual cycle (n = 17) and group 2 consisted of postmenopausal women (n = 17). Immunostaining of hormone receptors was performed using specific antibodies (DAKO, Copenhagen, Denmark) in cells from the internal anal sphincter, the vascular epithelium, and the squamous epithelium. The percentage of positivity of receptors and the association between age and receptor positivity were compared between the 2 groups.

RESULTS: Estrogen receptors were found in the internal anal sphincter in 23.5% in group 1 vs 11.8% in group 2 (P = .656). Progesterone receptors were found in 41.2% in group 1 vs 11.8% of group 2 (P = .118). Squamous epithelium showed estrogen receptors in 52.9% in group 1 vs 64.7% of group 2 (P = .388) and progesterone receptors in 17.6% and 0% in groups 1 and 2, respectively (P = .227). Vascular endothelium showed no receptors. Receptor positivity was not associated with age.

CONCLUSION: No significant differences were found in the detection of estrogen and progesterone receptors in structures of the anal canal in women in relation to menopausal status and age.

Author Information

1 Colorectal Surgery Unit, Department of Surgery, Hospital Universitari del Mar, Barcelona, Spain

2 Department of Pathology, Hospital Universitari del Mar, Barcelona, Spain

3 Department of General and Digestive Surgery, Parc Sanitari San Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain

Financial Disclosure: None reported.

Presented at the meeting of the European Society of Coloproctology, Prague, Czech Republic, September 22 to 25, 2009.

Correspondence: David Parés, M.D., Ph.D., Department of General and Digestive Surgery, Parc Sanitari Sant Joan de Déu, c/ Bonaventura Calopa 13, 08830, Sant Boi de Llobregat, Barcelona, Spain. E-mail: david.pares@pssjd.org

© The ASCRS 2010