Skip Navigation LinksHome > April 2009 - Volume 52 - Issue 4 > Outcomes and Prognostic Factors for Squamous-Cell Carcinoma...
Diseases of the Colon & Rectum:
doi: 10.1007/DCR.0b013e31819eb7f0
Original Contributions

Outcomes and Prognostic Factors for Squamous-Cell Carcinoma of the Anal Canal: Analysis of Patients From the National Cancer Data Base.

Bilimoria, Karl Y. M.D., M.S.1,2; Bentrem, David J. M.D.1; Rock, Colin E. B.S.1; Stewart, Andrew K. M.A.2; Ko, Clifford Y. M.D., M.S., M.S.H.S.2,3; Halverson, Amy M.D.1

Collapse Box

Abstract

PURPOSE: The objective of this study was to assess survival and prognostic factors for anal carcinoma in the population.

METHODS: Patients with squamous-cell carcinoma of the anal canal were identified from the National Cancer Data Base (1985-2000). Univariate and multivariable methods were used to assess factors associated with survival. Concordance was calculated to assess agreement between American Joint Committee on Cancer stage and actual outcome.

RESULTS: Nineteen thousand one hundred ninety-nine patients with anal carcinoma were identified (Stage I, 25.3 percent; Stage II, 51.8 percent; Stage III, 17.1 percent; Stage IV, 5.7 percent). Overall five-year survival was 58.0 percent. The American Joint Committee on Cancer (6th edition) staging system provided good survival discrimination by stage: I, 69.5 percent; II, 59.0 percent; III, 40.6 percent; and IV, 18.7 percent (concordance index, 0.663). On multivariable analysis, patients with anal carcinoma had a higher risk of death if they were male, ≥65 years old, black, living in lower median incomes areas, and had more advanced T stage tumors, nodal or distant metastases, or poorly differentiated cancers (P < 0.0001). There was not a significant difference in survival by hospital type or year of diagnosis.

CONCLUSION: Although tumor characteristics and staging affect prognosis, patient factors, such as gender, race, and socioeconomic status, are also important prognostic factors for squamous-cell carcinoma of the anal canal.

© The ASCRS 2009

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.