We describe the development and institution of an initiative based on a clinical diagnostic algorithm and treatment pathways, facilitated by cardiac nurse practitioners, for the treatment of the diverse group of patients with chest pain who seek treatment at our urban-based institution. We believe that our chest pain initiative incorporates previous strategies of rapid emergency department management with inpatient-based care while providing a framework for outpatient follow-up and secondary prevention. These strategies allow our hospital to meet its goals of providing chest pain patients with standardized, high-quality, and expeditious care, given the challenges faced by an academic urban hospital.