Background: The aim of this study was to investigate the safety and efficacy of dalteparin during an elective percutaneous coronary intervention (PCI) procedure in a large cohort.
Materials and methods: In this prospective, randomized, open-label design study, 733 patients undergoing elective PCI were divided into an unfractionated heparin group (group 1, 323 patients) or a dalteparin group (group 2, 410 patients). Blood samples were collected before and 18–24 h after the PCI procedure to determine the serum levels of cardiac troponin I (cTnI) and creatine kinase isoenzyme MB. Major adverse cardiac events (MACEs) and bleeding events during hospitalization were also recorded. Patients with an increased level of serum cTnI before PCI were excluded from the study.
Results: After PCI, the cTnI values were greater than three times the upper limit of normal in 43 cases (13.3%) in group 1 and 52 cases (12.7%) in group 2, without a statistically significant difference between the two groups (P=0.801). An increased creatine kinase isoenzyme MB level of greater than two times the upper limit of normal was found in 10 cases (3.1%) in group 1 and 12 cases (2.9%) in group 2, without a statistically significant difference between the two groups (P=0.894). Postoperative bleeding was observed in nine patients (2.8%) in group 1 and six patients (1.5%) in group 2. Postoperative MACEs were observed in two patients (0.6%) in group 1 and two patients (0.5%) in group 2. There were no significant differences between the two groups with respect to bleeding events or MACEs.
Conclusion: Our study showed that dalteparin might be as effective and safe as unfractionated heparin for anticoagulation during elective PCI.
aDepartment of Cardiology, The Second Hospital of Hebei Medical University
bDepartment of Cardiology, The Third Hospital of Shijiazhuang City
cDepartment of Cardiology, People’s Hospital of Shijiazhuang City
dDepartment of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang
eDepartment of Cardiology, General Hospital of Huabei Oilfield, Renqiu
fDepartment of Cardiology, People’s Hospital of Xingtai City, Xingtai
gDepartment of Cardiology, 252 Hospital of PLA, Baoding, China
Correspondence to Wei Cui, MD, Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China Tel: +86 311 66002115; fax: +86 311 66002115; e-mail: email@example.com
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Received February 24, 2014
Received in revised form April 15, 2014
Accepted April 17, 2014