Background: It has been shown that increased red blood cell distribution width (RDW) predicts adverse outcomes in cardiovascular disease and in patients undergoing a percutaneous coronary intervention. The aim of the present study was to assess the predictive value of preinterventional RDW on the development of in-stent restenosis (ISR) in patients undergoing stent implantation.
Materials and methods: In this retrospective study, we compared 131 patients with ISR and 138 patients without ISR who had undergone bare metal stent implantation.
Results: Preprocedural RDW was significantly higher in patients with ISR than those without restenosis (14.6±3.2 vs. 13.4±1.6%, P<0.001). Stent length was significantly longer in patients with than those without restenosis (17.9±5.6 vs. 16.2±5.2 mm, respectively, P=0.03). Compared with patients with restenosis, patients without restenosis had a lower rate of diabetes (28 vs. 61 patients, P=0.001), a significantly short period between two coronary angiographies (9.8±9.3 vs. 12.9±11.6 months, respectively, P=0.02), and lower triglyceride levels (133±53 vs. 198±121 mg/dl, respectively, P=0.05). In multivariate logistic regression analysis, diabetes mellitus, stent length, preprocedural RDW, and current smoking independently predicted ISR.
Conclusion: Increased preinterventional RDW significantly predicts bare metal stent restenosis and might represent a useful screening tool to stratify patients according to a higher or a lower risk of ISR after stent implantation in patients with stable and unstable angina pectoris.
aDepartment of Cardiology, Medical Park Hospital
bDepartment of Cardiology, School of Medicine, Istanbul Medipol University, Istanbul
cDepartment of Cardiology, School of Medicine, Kafkas University, Kars, Turkey
Correspondence to Dursun Duman, MD, Istanbul Medipol Hospital, Kosuyolu/Kadikoy, Istanbul 34718, Turkey Tel: +90 216 544 6666; fax: +90 216 545 2006; e-mail: firstname.lastname@example.org
Received January 2, 2014
Received in revised form January 29, 2014
Accepted February 11, 2014