Background: The interval between the peak and the end of the T wave (Tp–e interval) on 12-lead ECG is a measure of transmural dispersion of repolarization and may be related to malignant ventricular arrhythmias. The objective of this study was to investigate whether the Tp–e interval predicts in-hospital and long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing a primary percutaneous coronary intervention (pPCI).
Methods: This study included 488 consecutive patients with STEMI treated with pPCI. Electrocardiograms were obtained after pPCI and the Tp–e interval was measured in leads without ST-segment elevation.
Results: There were 46 (9.4%) deaths in the population, with a mean follow-up time of 21.1±10.2 months. The Tp–e interval was associated with not only in-hospital ventricular tachycardia/fibrillation, target vessel revascularization, and death but also long-term target vessel revascularization and death. Furthermore, the Tp–e interval measured using the tail method was found to be a significant predictor of long-term mortality in multivariable Cox analyses [odds ratio 1.018, 95% confidence interval (1.004–1.033)]. Findings were similar in the Tp–e interval and the heart rate-corrected Tp–e interval (cTp–e).
Conclusion: Tp–e and cTp–e measured using the tail method were found to be predictors of both in-hospital and long-term mortality.
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey
Correspondence to Kazim S. Özcan, MD, Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Barbaros Mahallesi, Bekir Sitki Sezgin Sokak, Özlem Sitesi, B Blok, Daire 9, 34087, Istanbul, Turkey Tel: +90 532 6742429/+90 216 545 47 36; fax: +90 216 561 38 37; e-mail: firstname.lastname@example.org
Received December 21, 2013
Received in revised form January 24, 2014
Accepted February 5, 2014