Background: It has been shown that increased red blood cell distribution width (RDW) predicts adverse outcomes in cardiovascular disease and in patients undergoing a percutaneous coronary intervention. The aim of the present study was to assess the predictive value of preinterventional RDW on the development of in-stent restenosis (ISR) in patients undergoing stent implantation.
Materials and methods: In this retrospective study, we compared 131 patients with ISR and 138 patients without ISR who had undergone bare metal stent implantation.
Results: Preprocedural RDW was significantly higher in patients with ISR than those without restenosis (14.6+/-3.2 vs. 13.4+/-1.6%, P<0.001). Stent length was significantly longer in patients with than those without restenosis (17.9+/-5.6 vs. 16.2+/-5.2 mm, respectively, P=0.03). Compared with patients with restenosis, patients without restenosis had a lower rate of diabetes (28 vs. 61 patients, P=0.001), a significantly short period between two coronary angiographies (9.8+/-9.3 vs. 12.9+/-11.6 months, respectively, P=0.02), and lower triglyceride levels (133+/-53 vs. 198+/-121 mg/dl, respectively, P=0.05). In multivariate logistic regression analysis, diabetes mellitus, stent length, preprocedural RDW, and current smoking independently predicted ISR.
Conclusion: Increased preinterventional RDW significantly predicts bare metal stent restenosis and might represent a useful screening tool to stratify patients according to a higher or a lower risk of ISR after stent implantation in patients with stable and unstable angina pectoris.
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