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Clinical and prognostic comparison between left ventricular transient dyskinesia and a first non-ST-segment elevation acute coronary syndrome

Núñez-Gil, Iván Javiera; Fernández-Ortiz, Antonioa; Pérez-Isla, Leopoldoa; Luaces, Maríab; García-Rubira, Juan Carlosa; Vivas, Davida; Gonzalez, Juan J.a; Alonso, Joaquínb; Zamorano, José Luisa; Macaya, Carlosa

doi: 10.1097/MCA.0b013e32830eab74
Pathophysiology and Natural History

Objectives: Apical ballooning shares features with acute coronary syndromes. Recently, atypical forms have been reported without apical involvement. Usually, the prognostic reports have compared them with ST-segment elevation infarction. Left ventricular transient dyskinesias (LVTD), however, frequently occur without ST-segment elevation and when present, these patients always have open arteries. Our aim was to assess the baseline features, clinical presentation, natural history and compare long-term prognosis in an LVTD-cohort with a first non-ST-segment elevation acute coronary syndrome (NSTEMI) group.

Methods: We performed a prospective observational study including consecutive patients in two groups: (i) LVTD group: 62 patients with this syndrome between 2003 and 2007. Inclusion criteria were LV segmental transient motion abnormalities; ECG new alterations and elevated troponin; absence of recent significant head trauma or obstructive coronary artery lesions. (ii) Control group: 169 patients admitted for a first NSTEMI in 2004.

Results: Median follow-up was 35 months. Mean age was 65 years. LVTD group included 83.9% females. NSTEMI group was predominantly males. Eleven in-hospital deaths happened in NSTEMI cohort and none in LVTD. Four patients in the LVTD group required readmission and two patients died. In the NSTEMI group, heart failure, unstable angina, myocardial infarction (P<0.001) and death (P=0.11) were more frequent. Cox regression showed that diabetes mellitus, significant onset mitral regurgitation and NSTEMI versus LVTD were found as event-independent predictors.

Conclusion: LVTD diagnosis represents a decreased risk of events when compared with classic non-ST-segment acute coronary syndrome, pointing out a different pathophysiologic mechanism.

aCardiology Department, Cardiovascular Institute, Hospital Clínico San Carlos

bCardiology Department, Hospital de Fuenlabrada, Madrid, Spain, Europe

Correspondence to Dr Iván Javier Núñez-Gil, Avda Prof Martin Lagos S/N. 28040 Madrid, Spain

Tel: +34 91 330 7645; fax: +34 91 330 3730;

e-mail: ibnsky@yahoo.es

Received 18 March 2008 Revised 26 May 2008 Accepted 20 June 2008

© 2008 Lippincott Williams & Wilkins, Inc.