Institutional members access full text with Ovid®

Share this article on:

Impact of Intraoperative Topical Hydroxypropyl Methylcellulose 2% Versus Sodium Hyaluronate 1.2% on Corneal Reepithelialization After Intentional Epithelial Debridement During Vitrectomy

Tosi, Gian Marco MD, PhD; Marigliani, Davide MD; Bacci, Tommaso MD; Balestrazzi, Angelo MD, PhD; Martone, Gianluca MD, PhD; Polito, Maria Sole MD

doi: 10.1097/ICO.0000000000000201
Clinical Science

Purpose: The aim of this study was to assess the impact of the intraoperative use of topical hydroxypropyl methylcellulose (HPMC) 2% versus sodium hyaluronate 1.2% on corneal reepithelialization time and final corneal status after intentional epithelial debridement during vitrectomy for proliferative vitreoretinopathy.

Methods: Forty eyes of 40 patients were included in the study, divided into 2 groups of 20 eyes. HPMC 2% and sodium hyaluronate 1.2% were used as corneal protectors in the first and second group, respectively. Patients' charts were reviewed to determine any differences between the HPMC 2% and sodium hyaluronate 1.2% groups in relation to the preoperative, intraoperative, and postoperative factors that could impact postoperative corneal reepithelialization. Postoperative reepithelialization time and final corneal status were recorded.

Results: No significant between-group differences in preoperative, intraoperative, and postoperative factors were found. Reepithelialization time was significantly shorter in the sodium hyaluronate 1.2% group than in the HPMC 2% group, although reepithelialization was eventually achieved in every patient in both groups. Corneal sequelae were significantly more frequent in the HPMC 2% group than in the sodium hyaluronate 1.2% group.

Conclusions: The choice of the ophthalmic viscosurgical device for intraoperative corneal protection may significantly influence the postoperative corneal status after complicated retinal detachment.

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Reprints: Gian M. Tosi, MD, PhD, Department of Medicine, Surgery and Neuroscience (Ophthalmology Section), University of Siena, Siena, Italy (e-mail: gmtosi@tin.it).

The authors have no funding or conflicts of interest to disclose.

Received March 26, 2014

Accepted June 10, 2014

© 2014 by Lippincott Williams & Wilkins.