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Cornea:
doi: 10.1097/ICO.0000000000000201
Clinical Science

Impact of Intraoperative Topical Hydroxypropyl Methylcellulose 2% Versus Sodium Hyaluronate 1.2% on Corneal Reepithelialization After Intentional Epithelial Debridement During Vitrectomy

Tosi, Gian Marco MD, PhD; Marigliani, Davide MD; Bacci, Tommaso MD; Balestrazzi, Angelo MD, PhD; Martone, Gianluca MD, PhD; Polito, Maria Sole MD

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Abstract

Purpose:

The aim of this study was to assess the impact of the intraoperative use of topical hydroxypropyl methylcellulose (HPMC) 2% versus sodium hyaluronate 1.2% on corneal reepithelialization time and final corneal status after intentional epithelial debridement during vitrectomy for proliferative vitreoretinopathy.

Methods:

Forty eyes of 40 patients were included in the study, divided into 2 groups of 20 eyes. HPMC 2% and sodium hyaluronate 1.2% were used as corneal protectors in the first and second group, respectively. Patients' charts were reviewed to determine any differences between the HPMC 2% and sodium hyaluronate 1.2% groups in relation to the preoperative, intraoperative, and postoperative factors that could impact postoperative corneal reepithelialization. Postoperative reepithelialization time and final corneal status were recorded.

Results:

No significant between-group differences in preoperative, intraoperative, and postoperative factors were found. Reepithelialization time was significantly shorter in the sodium hyaluronate 1.2% group than in the HPMC 2% group, although reepithelialization was eventually achieved in every patient in both groups. Corneal sequelae were significantly more frequent in the HPMC 2% group than in the sodium hyaluronate 1.2% group.

Conclusions:

The choice of the ophthalmic viscosurgical device for intraoperative corneal protection may significantly influence the postoperative corneal status after complicated retinal detachment.

Copyright © 2014 by Lippincott Williams & Wilkins

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