Combined Topical Application of a Regenerative Agent With a Bandage Contact Lens for the Treatment of Persistent Epithelial Defects

Kymionis, George D. MD, PhD*,†; Liakopoulos, Dimitrios A. MD*; Grentzelos, Michael A. MD*; Diakonis, Vasilios F. MD, PhD*; Klados, Nektarios E. MD*; Tsoulnaras, Konstantinos I. MD*; Tsilimbaris, Miltiadis K. MD, PhD*; Pallikaris, Ioannis G. MD, PhD*

Cornea:
doi: 10.1097/ICO.0000000000000169
Case Report
Abstract

Purpose: The aim of this study was to report 3 cases of persistent epithelial defects (PEDs) successfully treated with the combined topical application of a regenerative agent (RGTA; Cacicol20, OTR3, Paris, France) with a bandage contact lens (BCL).

Methods: This is a case series.

Results: Three patients suffering from a PED for 4–8 weeks and unresponsive to conventional therapy were treated with the combined application of an RGTA (Cacicol20) and a silicone hydrogel BCL. The PED healed in all patients after 4–21 days, and no side effects were noted.

Conclusions: The combination of an RGTA (Cacicol20) with a BCL seems to be an effective treatment for PED.

Author Information

*Faculty of Medicine, Vardinoyiannion Eye Institute of Crete (VEIC), University of Crete, Heraklion, Crete, Greece; and

Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL.

Reprints: George D. Kymionis, MD, PhD, Faculty of Medicine, Vardinoyiannion Eye Institute of Crete (VEIC), University of Crete, Heraklion, Crete 71003, Greece (e-mail: kymionis@med.uoc.com).

Supported in part by the special research account of the University of Crete.

The authors have no other funding or conflicts of interest to disclose.

Received March 25, 2014

Accepted April 27, 2014

© 2014 by Lippincott Williams & Wilkins.