Relationship Between IL1β-511C>T and ILRN VNTR Polymorphisms and KeratoconusPalamar, Melis MD*; Onay, Huseyin MD†; Ozdemir, Taha Resid MD†; Arslan, Esra MD†; Egrilmez, Sait MD*; Ozkinay, Ferda MD†; Yagci, Ayse MD*Cornea: February 2014 - Volume 33 - Issue 2 - p 145–147 doi: 10.1097/ICO.0000000000000027 Clinical Science Abstract Author Information Purpose: The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1β (IL1 β) (–511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC. Methods: A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1β (−511C>T) (rs16944) (polymerase chain reaction–restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated. Results: Genotype and allele distribution for IL1β (−511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05). Conclusions: Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1β-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population. Departments of *Ophthalmology and †Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey. Reprints: Melis Palamar, Department of Ophthalmology, Faculty of Medicine, Ege University, 35100 Bornova, Izmir, Turkey (e-mail: email@example.com). The authors have no funding or conflicts of interest to disclose. Received July 19, 2013 Accepted October 07, 2013 © 2014 by Lippincott Williams & Wilkins.