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Is There a Relationship Between Pathologic Myopia and Dry Eye Syndrome?

Ilhan, Nilufer MD; Ilhan, Ozgur MD; Ayhan Tuzcu, Esra MD; Daglioglu, Mutlu Cihan MD; Coskun, Mesut MD; Parlakfikirer, Nihan MD; Keskin, Ugurcan MD

doi: 10.1097/ICO.0000000000000033
Clinical Science

Purpose: The aim of this study was to investigate the relationship between pathologic myopia and the dry eye syndrome.

Methods: Forty-five patients with a spherical equivalence (SE) greater than −6.0 diopters (D) and an axial length (AL) >26.5 mm were assigned to the pathological myopia group (group 1). Forty-four healthy individuals were selected from subjects with emmetropia whose SE values ranged from −1.0 to +1.0 D (group 2). Ocular surface disease index (OSDI) scores of all the patients were determined. All the participants underwent the following: Schirmer 1 test without anesthesia, corneal staining, tear break-up time (TBUT), Schirmer 1 test with anesthesia, and AL measurement.

Results: The mean age of group 1 and group 2 patients was 40.2 ± 12.3 and 38.8 ± 9.3 years. The mean values of SE, keratometry, and AL were −9.6 ± 3.8 D, 43.9 ± 1.1 D, and 27.4 ± 0.6 mm in group 1 and −0.1 ± 0.5 D, 42.3 ± 1.4 D, and 23.0 ± 0.2 mm in group 2. The mean values of the Schirmer 1 test without and with anesthesia were 14.4 ± 6.1 and 9.5 ± 4.5 mm in group 1 and 16.7 ± 6.2 and 11.4 ± 6.0 mm in group 2. The mean TBUT in group 1 was 7.2 ± 3.4 seconds, whereas that in group 2 was 13.6 ± 3.7 seconds. There was a significant difference between the groups in SE, keratometry, AL, TBUT, and OSDI scores (P < 0.001).

Conclusions: Patients with pathologic myopia have lower TBUT scores and higher OSDI scores when compared with healthy individuals.

Author Information

Department of Ophthalmology, Mustafa Kemal University, Faculty of Medicine, Antakya, Hatay, Turkey.

Reprints: Nilufer Ilhan, Faculty of Medicine, Department of Ophthalmology, Mustafa Kemal University, 31120, Antakya, Hatay, Turkey (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received June 11, 2013

Accepted October 11, 2013

© 2014 by Lippincott Williams & Wilkins.