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Is There a Relationship Between Pathologic Myopia and Dry Eye Syndrome?

Ilhan, Nilufer MD; Ilhan, Ozgur MD; Ayhan Tuzcu, Esra MD; Daglioglu, Mutlu Cihan MD; Coskun, Mesut MD; Parlakfikirer, Nihan MD; Keskin, Ugurcan MD

doi: 10.1097/ICO.0000000000000033
Clinical Science

Purpose: The aim of this study was to investigate the relationship between pathologic myopia and the dry eye syndrome.

Methods: Forty-five patients with a spherical equivalence (SE) greater than −6.0 diopters (D) and an axial length (AL) >26.5 mm were assigned to the pathological myopia group (group 1). Forty-four healthy individuals were selected from subjects with emmetropia whose SE values ranged from −1.0 to +1.0 D (group 2). Ocular surface disease index (OSDI) scores of all the patients were determined. All the participants underwent the following: Schirmer 1 test without anesthesia, corneal staining, tear break-up time (TBUT), Schirmer 1 test with anesthesia, and AL measurement.

Results: The mean age of group 1 and group 2 patients was 40.2 ± 12.3 and 38.8 ± 9.3 years. The mean values of SE, keratometry, and AL were −9.6 ± 3.8 D, 43.9 ± 1.1 D, and 27.4 ± 0.6 mm in group 1 and −0.1 ± 0.5 D, 42.3 ± 1.4 D, and 23.0 ± 0.2 mm in group 2. The mean values of the Schirmer 1 test without and with anesthesia were 14.4 ± 6.1 and 9.5 ± 4.5 mm in group 1 and 16.7 ± 6.2 and 11.4 ± 6.0 mm in group 2. The mean TBUT in group 1 was 7.2 ± 3.4 seconds, whereas that in group 2 was 13.6 ± 3.7 seconds. There was a significant difference between the groups in SE, keratometry, AL, TBUT, and OSDI scores (P < 0.001).

Conclusions: Patients with pathologic myopia have lower TBUT scores and higher OSDI scores when compared with healthy individuals.

Department of Ophthalmology, Mustafa Kemal University, Faculty of Medicine, Antakya, Hatay, Turkey.

Reprints: Nilufer Ilhan, Faculty of Medicine, Department of Ophthalmology, Mustafa Kemal University, 31120, Antakya, Hatay, Turkey (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received June 11, 2013

Accepted October 11, 2013

© 2014 by Lippincott Williams & Wilkins.