Purpose: To examine the effect of topical ranibizumab on clinically stable corneal neovascularization (NV).
Methods: This was a prospective, open-label, monocentric, uncontrolled noncomparative study. Ten eyes of 9 patients with corneal NV received topical ranibizumab (1%) 4 times a day for 3 weeks with a follow-up period of 16 weeks. The main corneal NV outcome measures were: neovascular area, the area occupied by the corneal neovessels; vessel caliber (VC), the mean diameter of the corneal neovessels; and invasion area (IA), the fraction of the total cornea area covered by the vessels. This study was conducted at the Massachusetts Eye and Ear Infirmary, Boston, MA.
Results: Statistically significant decreases in neovascular area (55.3%, P < 0.001), which lasted through 16 weeks, and VC (59%, P < 0.001), which continued to improve up to week 16, were observed after treatment. No significant decrease was observed in IA (12.3%, P = 0.49). There was no statistically significant change in visual acuity or intraocular pressure. No adverse events ascribed to the treatment were noted.
Conclusions: Topical application of ranibizumab is effective in reducing the severity of corneal NV in the context of established corneal NV, mostly through decrease in VC rather than IA.
*G.B. Bietti Eye Foundation-IRCCS, Rome, Italy
†Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
Reprints: Giulio Ferrari, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114 (e-mail: firstname.lastname@example.org).
G. Ferrari has received a grant from the Bietti Eye Foundation, IRCCS, Rome, Italy; R. Dana received financial support from Genentech, Inc, South San Francisco, CA and NIH EY-019098. The other authors have no financial or conflicts of interest to disclose.
G. Ferrari and M.H. Dastjerdi contributed equally to this work.
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Received August 16, 2012
Accepted October 02, 2012