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Cornea:
doi: 10.1097/ICO.0b013e31826a1e53
Clinical Science

Surgical Resection and Amniotic Membrane Transplantation for Treatment of Refractory Giant Papillae in Vernal Keratoconjunctivitis

Guo, Ping MD*,†; Kheirkhah, Ahmad MD†,‡; Zhou, Wei-wei MD*; Qin, Lei MD*; Shen, Xiao-li MD*

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Abstract

Purpose: The aim of this study was to evaluate the outcome of surgical resection and amniotic membrane transplantation (AMT) for treatment of refractory symptomatic giant papillae in vernal keratoconjunctivitis (VKC).

Methods: This is a retrospective study of 13 eyes of 9 patients with refractory giant papillae associated with corneal shield ulcer and/or punctate epithelial erosions who underwent surgical resection of the papillae combined with AMT to cover the tarsal conjunctival defect.

Results: During 14.2 ± 4.2 months of postoperative follow-up, smooth tarsal conjunctival surface was achieved in all cases, with no recurrence of the giant papillae in any eye. Corneal shield ulcers and punctate epithelial erosions healed within 2 weeks after surgery and did not recur during the follow-up. Best-corrected visual acuity improved from 0.26 ± 0.21 logarithm of the minimum angle of resolution preoperatively to 0.02 ± 0.04 logarithm of the minimum angle of resolution postoperatively (P = 0.01). Three patients experienced recurrence of VKC symptoms, but without giant papillae, which could be well controlled by topical medications.

Conclusions: Surgical resection combined with AMT is an effective procedure for treatment of refractory giant papillae in patients with VKC.

© 2013 by Lippincott Williams & Wilkins.

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