Effects of Chalazion Excision on Ocular AberrationsSabermoghaddam, Ali A. MD; Zarei-Ghanavati, Siamak MD, FICO; Abrishami, Mojtaba MDCornea: June 2013 - Volume 32 - Issue 6 - p 757–760 doi: 10.1097/ICO.0b013e318268d6b3 Clinical Science Abstract Author Information Purpose: The goal of this study was to compare higher-order aberrations before and after upper lid chalazion excision. Methods: Fourteen eyes from 12 patients (8 females, mean age: 28.7 ± 2.7 years) with upper lid chalazion were enrolled in this prospective interventional case series. Chalazia were excised by standard transconjunctival vertical incision. Ocular aberrations were evaluated by aberrometry (ZyWave) before and 2 months after chalazion excision. Results: Root mean square of total higher-order aberrations decreased from 0.67 ± 0.12 to 0.43 ± 0.15 μm (P = 0.012) after excision. The root mean square of Zernike orders in the vertical and horizontal trefoil and horizontal coma were decreased after excision. Orbscan IIz tomography showed a statistically significant decrease in 5 mm zone irregularity (P = 0.027) and an increase in minimum simulated keratometry after surgery (P = 0.046). Conclusions: Chalazion increases higher-order aberrations, as measured by the Hartmann–Shack aberrometer, which could affect the preoperative evaluation and results of refractive surgery, especially wavefront-guided approaches. Chalazion excision could reduce ocular aberrations and is recommended before refractive surgeries. Eye Research Center, Khatam-al-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Reprints: Mojtaba Abrishami, Eye Research Center, Khatam-al-Anbia Hospital, Mashhad University of Medical Sciences, Abutaleb Cross, Qarani Boulevard, Mashhad 91959-61151, Iran (e-mail: email@example.com). The authors declare that there is no conflict of interest. Received November 6, 2011 Accepted July 9, 2012 © 2013 by Lippincott Williams & Wilkins.