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Depiction of Cavity Formation in Terrien Marginal Degeneration by Anterior Segment Optical Coherence Tomography

Hattori, Takaaki MD, PhD; Kumakura, Shigeto MD, PhD; Mori, Hideki MD, PhD; Goto, Hiroshi MD, PhD

doi: 10.1097/ICO.0b013e318259c970
Clinical Science

Purpose: To evaluate detailed morphologic changes of Terrien marginal degeneration (TMD) using anterior segment optical coherence tomography (AS-OCT).

Methods: Two patients with TMD were examined by 1310-nm wavelength swept source optical coherence tomography, corneal topography, and slit-lamp microscopy.

Results: AS-OCT depicted corneal thinning with intact epithelial layer in the peripheral cornea of both patients. Moreover, AS-OCT images of both patients clearly showed cavity formation surrounded and enclosed by intact epithelial and endothelial layers in the thinned area.

Conclusion: We demonstrate here the existence of cavity formation in the peripheral cornea with TMD. This observation suggests a possibility that corneal thinning in TMD is associated with cavity formation in the corneal stroma. AS-OCT is useful for the observation of detailed morphologic changes of diseased cornea.

Author Information

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

Reprints: Takaaki Hattori, Department of Ophthalmology, Tokyo Medical University, Nishishinjuku 6-7-1, Shinjukuku, Tokyo, Japan (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received October 23, 2011

Accepted April 8, 2012

© 2013 by Lippincott Williams & Wilkins.