Depiction of Cavity Formation in Terrien Marginal Degeneration by Anterior Segment Optical Coherence TomographyHattori, Takaaki MD, PhD; Kumakura, Shigeto MD, PhD; Mori, Hideki MD, PhD; Goto, Hiroshi MD, PhDCornea: May 2013 - Volume 32 - Issue 5 - p 615–618 doi: 10.1097/ICO.0b013e318259c970 Clinical Science Abstract Author Information Purpose: To evaluate detailed morphologic changes of Terrien marginal degeneration (TMD) using anterior segment optical coherence tomography (AS-OCT). Methods: Two patients with TMD were examined by 1310-nm wavelength swept source optical coherence tomography, corneal topography, and slit-lamp microscopy. Results: AS-OCT depicted corneal thinning with intact epithelial layer in the peripheral cornea of both patients. Moreover, AS-OCT images of both patients clearly showed cavity formation surrounded and enclosed by intact epithelial and endothelial layers in the thinned area. Conclusion: We demonstrate here the existence of cavity formation in the peripheral cornea with TMD. This observation suggests a possibility that corneal thinning in TMD is associated with cavity formation in the corneal stroma. AS-OCT is useful for the observation of detailed morphologic changes of diseased cornea. Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. Reprints: Takaaki Hattori, Department of Ophthalmology, Tokyo Medical University, Nishishinjuku 6-7-1, Shinjukuku, Tokyo, Japan (e-mail: firstname.lastname@example.org). The authors have no funding or conflicts of interest to disclose. Received October 23, 2011 Accepted April 8, 2012 © 2013 by Lippincott Williams & Wilkins.